Effects of Ethanol Intake on Lipoproteins
Effects of Ethanol Intake on Lipoproteins
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DOI：
10.1007/s11883-012-0230-7
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发表时间：
2012-04-01
影响因子：
5.8
通讯作者：
Brinton, Eliot A.
中科院分区：
文献类型：
--
作者：
Brinton, Eliot A.
这些综述讨论了乙醇对脂蛋白水平和与动脉粥样硬化和心血管疾病 (CVD) 相关的功能的影响，特别强调了最近的出版物。最近，人们已经探讨了乙醇对高密度脂蛋白胆固醇 (HDL-C)、低密度脂蛋白胆固醇 (LDL-C)、甘油三酯 (TG) 和其他 CVD 危险因素的影响。其他新数据涉及遗传和人口预测因素以及这些反应的机制。毫不奇怪，最近的一些研究结果证实了早期看似已得到充分证实的发现，而另一些研究则与之前的发现不同。先前和最近的证据表明，适量、定期摄入乙醇可以使高密度脂蛋白、其他 CVD 危险因素和 CVD 事件发生率发生有利变化，并且最近的出版物探讨了这种关系的机制。然而，由于缺乏乙醇的随机对照临床试验以及乙醇消费的潜在危害，这些发现在临床实践中的应用仍然存在问题。
These review discuses the effects of ethanol on lipoprotein levels and function as related to atherosclerosis and cardiovascular disease (CVD), with special emphasis on recent publications. Ethanol's effects on high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG), and other CVD risk factors recently have been explored. Other new data address genetic and demographic predictors and mechanisms of these responses. Not surprisingly, the results of some recent studies corroborate, whereas others differ from, earlier seemingly well-established findings. Prior and recent evidence shows favorable changes in HDL, other CVD risk factors, and CVD event rates with moderate, regular ethanol intake, and recent publications have explored the mechanisms of this relationship. Application of these findings in clinical practice remains problematic, however, due to the lack of randomized, controlled clinical trials of ethanol and due to the potential hazards of ethanol consumption.