In the absence of a CD40 signal, B cells are tolerogenic.
In the absence of a CD40 signal, B cells are tolerogenic.
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在没有 CD40 信号的情况下，B 细胞具有耐受性。
DOI：
10.1016/1074-7613(95)90009-8
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发表时间：
1995
期刊：
影响因子：
32.4
通讯作者：
Flavell,RA
中科院分区：
文献类型：
--
作者：
Buhlmann,JE;Foy,TM;Aruffo,A;Crassi,KM;Ledbetter,JA;Green,WR;Xu,JC;Shultz,LD;Roopesian,D;Flavell,RA
当B细胞通过CD40失去信号时，它们表现出诱导T细胞耐受的能力。体内注射抗gp39和异源B细胞可降低小鼠产生同种异体反应的能力。耐受诱导是针对表达在同种异体B细胞上的单倍型。分别给予抗gp39和II类缺陷的B细胞或I类缺陷的B细胞，在CD8和CD4区诱导选择性无反应性。正如抗gp39治疗的研究预测的那样，给gp39基因缺陷的小鼠注射B细胞会导致同种异体特异性反应减弱。综上所述，这些数据与剥夺CD40信号会导致B细胞耐受性增强的假设是一致的。这些研究提供了对静息B细胞耐受能力的见解，并勾勒出了一种开发这一功能的实用方法。
When B cells are deprived of signaling through CD40, they exhibit the ability to induce T cell tolerance. The in vivo administration of antigp39 and aliogeneic B cells diminished the ability of mice to mount an allogenelc response. Tolerance induction was specific for the haplotype expressed on the allogeneic B cells. Selective ailospecific unresponsiveness was induced in the CD8 and CD4 compartments by the administratlon of antigp39 and class ii-deficient B cells or class I-deficient B cells, respectively. As predicted by studies with anti-gp39 treatment, diminished allospecific responsiveness was induced by the administration of B cells to mice genetically deficient in gp39. Taken together, these data are consistent with the premise that deprivation of CD40 signaling engenders B cells with enhanced tolerogsniclty. These studles provide insights into the tolerogenic capaclty of resting B ceils and outlines a practical approach to exploit this function.