Electronics for a Safe Direct Current Stimulator.
Electronics for a Safe Direct Current Stimulator.
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用于安全直流刺激器的电子器件。
DOI：
10.1109/biocas.2017.8325191
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Fridman,Gene
中科院分区：
文献类型：
--
作者：
Ou,Patrick;Fridman,Gene
市售的神经假体虽然成功且有效，但由于其依赖于脉动刺激，其功能受到限制。直流电（DC）已被证明具有很大的潜力，用于神经调节的目的;然而，由于电极的电荷注入阈值，直流电不能直接施加到神经元。我们正在开发一种安全的直流电刺激器（SDCS），它可以应用离子直流电（iDC），而不会引起有毒的电化学反应。SDCS的当前设计使用一系列八个阀与四个电极结合来整流微流体通道中的离子电流。本文概述了设计，实施和测试的电子SDCS。这些电子器件最终将与设备原型中的单独微流体回路连接。测试电子设备的输出证实符合其设计要求。SDCS电子器件的完成使iDC作为神经调节机制的进一步发展成为可能。
Commercially available neuroprostheses, while successful and effective, are limited in their functionality by their reliance on pulsatile stimulation. Direct current (DC) has been shown to have great potential for the purposes of neuromodulation; however, direct current cannot be applied directly to neurons due to the charge injection thresholds of electrodes. We are developing a Safe Direct Current Stimulator (SDCS) that applies ionic direct current (iDC) without inducing toxic electrochemical reactions. The current design of the SDCS uses a series of eight valves in conjunction with four electrodes to rectify ionic current in microfluidic channels. This paper outlines the design, implementation, and testing of the electronics of the SDCS. These electronics will ultimately be interfaced with a separate microfluidic circuit in the device prototype. Testing the outputs of the electronics confirmed adherence to its design requirements. The completion of the SDCS electronics enables the further development of iDC as a mechanism for neuromodulation.