Phosphorylation of both 47 and 49kDa proteins accompanies superoxide release by neutrophils.

Phosphorylation of both 47 and 49kDa proteins accompanies superoxide release by neutrophils.
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47 和 49kDa 蛋白质的磷酸化伴随着中性粒细胞释放超氧化物。

DOI:
10.1016/0006-291x(89)92825-8
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发表时间:
1989
影响因子:
3.1
通讯作者:
Karnovsky,ML
Karnovsky,ML
中科院分区:
生物学4区
文献类型:
--
作者:
Badwey,JA;Heyworth,PG;Karnovsky,ML

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Neutrophils stimulated with activators of protein kinase C (ie, 4β-phorbol 12-myristate 13-acetate; sn-1, 2-dioctanoylglycerol) exhibit a dramatic, dose-dependent incorporation of 32 P [P 1] into two proteins with molecular weights of ca. 47 and 49kDa. Proteins of the same molecular weights are also labelled when the cells are stimulated with a chemotactic peptide. However, with the latter stimulus, labelling of the 47kDa species is transient whereas that of the 49kDa entity persists. Labelling of both proteins always accompanied the release of O 2− stimulated by these agents. The kinetics of labelling are compatible with the involvement of both phosphoproteins in the stimulation of these cells.
来自常染色体隐性慢性肉芽肿病患者的刺激中性粒细胞未能磷酸化 Mr-44,000 蛋白
DOI: 10.1038/316547a0
发表时间: 1985
期刊: Nature
影响因子: 64.8
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DOI: --
发表时间: 1983
期刊: Blood
影响因子: 20.3
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DOI: --
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期刊: Biochemical and Biophysical Research Communications - BBRC
影响因子: --
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DOI: 10.1016/0003-9861(88)90300-1
发表时间: 1988
影响因子: 3.9
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蛋白激酶 C 参与 46 kDa 蛋白的磷酸化,在完整的豚鼠多形核白细胞中,该蛋白的磷酸化与 NADPH 氧化酶的激活同时进行。
DOI: --
发表时间: 1986
期刊: Biochimica et Biophysica Acta
影响因子: --
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