Sebum analysis of individuals with and without acne
Sebum analysis of individuals with and without acne
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DOI：
10.4161/derm.1.3.8473
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Eisinger, Magdalena
中科院分区：
文献类型：
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作者：
Pappas, Apostolos;Johnsen, Stefanie;Eisinger, Magdalena
进行初步研究以比较来自未受影响和痤疮影响的个体的皮脂的脂质组分。招募了9名男性，15-20岁，没有痤疮，或患有中度至重度痤疮。每个受试者的面部图像均采用常规、偏振光和荧光灯拍摄。在使用皮脂贴收集皮脂后分析皮肤表面脂质。正如预期的那样，痤疮受试者比对照受试者有更多的皮脂（59%）。游离脂肪酸是唯一的脂质组，减少了痤疮的皮脂。两组之间差异最大的特定脂质是角鲨烯，其在痤疮受试者中定量上调2.2倍。与对照组相比，痤疮患者的角鲨烯在总皮脂脂质中所占比例也显著更大（20%对15%）。角鲨烯含量的增加可能代表了易患痤疮皮肤的脂质标志物。
A pilot study was conducted to compare lipid components of sebum from unaffected and acne-affected individuals. Nine males, 15-20 years old, with no acne, or with moderate to severe acne, were recruited. Facial images were taken with regular, polarized and fluorescent lights for each subject. Skin surface lipids were analyzed following collection of sebum using sebutapes. As expected, the subjects with acne had more (59%) sebum than the control subjects. Free fatty acids were the only lipid group that was reduced in the sebum of acne subjects. The specific lipid that differed the most between the two groups was squalene, which was upregulated in acne subjects by 2.2-fold on a quantitative basis. Squalene also represented a significantly greater proportion of the total sebaceous lipids in acne patients compared to controls (20% vs. 15%). The increase in the amount of squalene could represent a lipid marker for acne prone skin.