Dopamine therapy is associated with impaired cerebral autoregulation in preterm infants
Dopamine therapy is associated with impaired cerebral autoregulation in preterm infants
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DOI：
10.1111/apa.12817
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发表时间：
2014-12-01
期刊：
影响因子：
3.8
通讯作者：
Greisen, Gorm
中科院分区：
文献类型：
--
作者：
Eriksen, Vibeke R.;Hahn, Gitte H.;Greisen, Gorm
目的低血压是新生儿常见的问题，与死亡率和发病率的增加有关。多巴胺是最常用的抗水肿药物治疗，但从未被证明可以改善神经功能。本研究验证了我们的假设，多巴胺影响脑自动调节（CA）。MethodsNear-infrared spectroscopy被用来测量脑氧合指数在60个极早产儿，和平均动脉血压进行了监测，对结束他们的第一天的生活。测量连续进行2至3小时。CA被量化为脑氧饱和度指数（考克斯）。ResultsWe治疗13的60名婴儿（22%）与多巴胺在测量。多巴胺组的考克斯高于未治疗组（0.41 ± 0.25 vs. 0.08 ± 0.25，p
AimHypotension is a common problem in newborn infants and is associated with increased mortality and morbidity. Dopamine is the most commonly used antihypotensive drug therapy, but has never been shown to improve neurological outcomes. This study tested our hypothesis that dopamine affects cerebral autoregulation (CA).MethodsNear-infrared spectroscopy was used to measure the cerebral oxygenation index in 60 very preterm infants, and mean arterial blood pressure was monitored towards the end of their first day of life. Measurements were performed continuously for two to three hour periods. CA was quantified as the cerebral oximetry index (COx).ResultsWe treated 13 of the 60 infants (22%) with dopamine during the measurements. COx was higher in the dopamine group than the untreated group (0.410.25 vs. 0.08 +/- 0.25, p