Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells
Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells
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DOI：
10.1016/s1535-6108(03)00107-7
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发表时间：
2003-05-01
期刊：
影响因子：
50.3
通讯作者：
Ross, TS
中科院分区：
文献类型：
--
作者：
Rao, DS;Bradley, SV;Ross, TS
网格蛋白相关蛋白亨廷顿蛋白相互作用蛋白1 （HIP1）在多种人类上皮肿瘤中过表达。在这里，我们报道了HIP1是一种转化细胞的新型癌蛋白。与rasv12转化的细胞相比，hip1转化的细胞具有参与网格蛋白运输的多种受体的失调。例子包括表皮生长因子受体（EGFR）和转铁蛋白受体的上调。此外，hip1转化细胞中转铁蛋白和EGF的积累增加，表达EGFR的乳腺肿瘤也有HIPI上调。因此，HIP1过表达促进肿瘤形成，并与受体运输的普遍改变有关。HIP1是第一个直接参与肿瘤形成的内吞蛋白。
The clathrin-associated protein, Huntingtin Interacting Protein 1 (HIP1), is overexpressed in multiple human epithelial tumors. Here, we report that HIP1 is a novel oncoprotein that transforms cells. HIP1-transformed cells, in contrast to RasV12-transformed cells, have dysregulation of multiple receptors involved in clathrin trafficking. Examples include upregulation of the epidermal growth factor receptor (EGFR) and the transferrin receptor. Furthermore, accumulation of transferrin and EGF in the HIP1-transformed cells was increased, and breast tumors that had EGFR expressed also had HIPI upregulated. Thus, HIP1 overexpression promotes tumor formation and is associated with a general alteration in receptor trafficking. HIP1 is the first endocytic protein to be directly implicated in tumor formation.