The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus
The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus
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DOI：
10.1016/j.vaccine.2005.04.036
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发表时间：
2005-09-15
期刊：
影响因子：
5.5
通讯作者：
Yamshchikov, V
中科院分区：
文献类型：
--
作者：
Yamshchikov, G;Borisevich, V;Yamshchikov, V
参与黄病毒研究的七名志愿者已接种商业日本脑炎和黄热病疫苗 JE-VAX 和 YF-VAX。所有捐赠者均发现与西尼罗河病毒 (WNV) 抗体反应具有强烈的同源性和交叉反应性，滴度为 1: 1600 至 1: 51200。所有捐献者均产生高水平的黄热病病毒（YFV）和日本脑炎病毒（JEV）中和抗体，滴度分别为1:50至1:1600和1:20至1:640，以及滴度为1:10至1:80的西尼罗河病毒中和抗体。相比之下，在所有免疫供体中均检测到主要是 YF 特异性细胞介导的免疫。对 YFV 的反应是持久的，但抗 JEV 体液免疫被发现随着时间的推移而降低。交叉反应性抗西尼罗河病毒反应遵循相同的趋势，在免疫后 4 年降至可检测水平以下，并在乙脑疫苗加强免疫后急剧恢复。因此，使用商业黄病毒乙脑疫苗进行免疫可能对接触西尼罗河病毒的高风险个体有益，例如参与西尼罗河病毒研究的人员。 (c) 2005 Elsevier Ltd. 保留所有权利。
Seven volunteers involved in flavivirus studies have been immunized with commercial Japanese encephalitis and yellow fever vaccines JE-VAX and YF-VAX. Strong homologous and cross-reactive with West Nile virus (WNV) antibody responses with titers 1: 1600 to 1: 51200 were found in all donors. All donors developed high levels of yellow fever virus (YFV) and Japanese encephalitis virus (JEV) neutralizing antibodies with titers 1:50 to 1:1600 and 1:20 to 1:640, respectively, and WNV neutralizing antibodies with titers 1:10 to 1:80. In contrast, predominantly YF-specific cell-mediated immunity was detected in all immunized donors. Responses to YFV were long lasting, but the anti-JEV humoral immunity was found to decrease with time. Cross-reactive anti-WNV responses were following the same trend dropping below detectable level at 4 years post-immunization and sharply coming back after booster immunization with the JE vaccine. Thus, immunization with the commercial flavivirus JE vaccine may be beneficial for individuals at high risk of exposure to WNV, such as personnel involved in WN research. (c) 2005 Elsevier Ltd. All rights reserved.