Staphylococcus aureus in a neonatal care center: methicillin-susceptible strains should be a main concern.
Staphylococcus aureus in a neonatal care center: methicillin-susceptible strains should be a main concern.
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DOI：
10.1186/2047-2994-3-21
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发表时间：
2014
影响因子：
5.5
通讯作者：
Parer S
中科院分区：
文献类型：
--
作者：
Romano-Bertrand S;Filleron A;Mesnage R;Lotthé A;Didelot MN;Burgel L;Jumas Bilak E;Cambonie G;Parer S
在甲氧西林敏感金黄色葡萄球菌（MSSA）爆发的背景下，我们的目的是提高我们的认识金黄色葡萄球菌（SA）流行病学在新生儿护理中心（NCC）的三级护理教学医院。我们对SA携带者、定植或感染患者进行了为期一年的完整回顾。计算每月SA肠道携带、定植和感染的患病率和发病率，并分析感染类型。在MSSA暴发期间，研究了菌株的耐药性、毒力基因含量和脉冲场凝胶电泳比较指纹图谱。通过直接观察性审计评估手卫生和导管相关做法。为了寻找SA水库，进行了环境调查。流行病学分析显示在SA流行背景下有2 - 3个流行峰。在NCC， 2009年期间，MSSA的总体患病率未低于5.5%，而MRSA的平均患病率约为1.53%。对感染病例的分析表明，此次暴发与导管相关感染的出现相对应，可能与在高定植压力背景下放松感染控制措施有关。医护人员的白大褂似乎是一个潜在的环境水库，可以使病房内的SA循环持续下去。本报告强调了将MSSA与耐甲氧西林SA纳入NCC流行病学监测计划的重要性。
In the context of a methicillin-susceptible Staphylococcus aureus (MSSA) outbreak, we aimed to improve our knowledge of S. aureus (SA) epidemiology in the neonatal care center (NCC) of a tertiary care teaching hospital. We performed a complete one-year review of SA carrier, colonized or infected patients. Monthly prevalence and incidence of SA intestinal carriage, colonization and infection were calculated and the types of infection analysed. During the MSSA outbreak, strains were studied for antimicrobial resistance, content of virulence genes and comparative fingerprint in Pulsed-Field Gel Electrophoresis. Hand hygiene and catheter-related practices were assessed by direct observational audits. Environmental investigation was performed in search of a SA reservoir. Epidemiological analyses showed 2 or 3 prevalence peaks on a background of SA endemicity. In the NCC, during 2009, overall MSSA prevalence did not decrease below 5.5%, while mean MRSA prevalence was about 1.53%. Analysis of infection cases revealed that the outbreak corresponded to the emergence of catheter-related infections and was probably related to the relaxation in infection control practices in a context of high colonization pressure. Health care workers’ white coats appeared as a potential environmental reservoir that could perpetuate SA circulation in the ward. This report emphasizes the importance of integrating MSSA along with methicillin-resistant SA in a program of epidemiological surveillance in the NCC.
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影响因子：
2.7
作者：
Boers, S. A.;van Ess, I.;Diederen, B. M. W.
通讯作者：
Diederen, B. M. W.
影响因子：
9.4
作者：
Corne, P;Marchandin, HN;Bañuls, AL
通讯作者：
Bañuls, AL
影响因子：
9.4
作者：
van der Mee-Marquet, Nathalie;Epinette, Christophe;Quentin, Roland
通讯作者：
Quentin, Roland
影响因子：
4.5
作者：
Bertin, Mary L.;Vinski, Joan;Goldfarb, Johanna
通讯作者：
Goldfarb, Johanna
影响因子：
8
作者：
Healy, CM;Palazzi, DL;Baker, CJ
通讯作者：
Baker, CJ