Epstein-Barr virus coinfection and recombination in non-human immunodeficiency virus-associated oral hairy leukoplakia.
Epstein-Barr virus coinfection and recombination in non-human immunodeficiency virus-associated oral hairy leukoplakia.
复制标题
非人类免疫缺陷病毒相关口腔毛状白斑中的 Epstein-Barr 病毒共感染和重组。
DOI：
10.1093/infdis/171.5.1122
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Raab-Traub,N
中科院分区：
文献类型：
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作者：
Walling,DM;Clark,NM;Markovitz,DM;Frank,TS;Braun,DK;Eisenberg,E;Krutchkoff,DJ;Felix,DH;Raab-Traub,N
人类免疫缺陷病毒相关性口腔毛状白斑(HLP)以与多种类型和毒株的EB病毒(EBV)混合感染并在EBV基因组内重组为特征。对HIV血清阴性、免疫抑制和免疫功能正常的HLP患者进行检测，以确定EBV混合感染和重组在HLP发生发展中的致病作用。在HIV血清阴性的HLP患者的HLP标本和外周血淋巴细胞(PBL)中均检测到多种EB病毒混合感染株。在4名患者中的3名患者的HLP样本中检测到一种特殊的EBV株。此外，在HLP内生产性复制过程中的病毒重组产生了潜伏膜蛋白-L(LMP-L)和核抗原-Z(EBNA-2)基因的变体。在PBL中也检测到一些变异体。因此，在HLP患者中，EBV合并感染和重组是一致的发现，无论其免疫状态如何。病毒介导的决定因素可能是EBV致病的重要特征。
Human immunodeficiency virus-associated oral hairy leukoplakia (HLP) is characterized by coinfection with multiple types and strains of Epstein-Barr virus (EBV) and recombination within the EBV genome. HIV-seronegative immunosuppressed and immunocompetent patients with HLP were examined to determine the pathogenic contribution of EBV coinfection and recombination to the development of HLP. Multiple coinfecting EBV strains were detected in both HLP specimens and peripheral blood lymphocytes (PBL) of HIV-seronegative persons with HLP. One specific EBV strain was detected in HLP specimens from 3 of 4 patients. Also, viral recombination during productive replication within HLP generated variants of the latent membrane protein-l (LMP-l) and nuclear antigen-Z (EBNA-2) genes. Some variants were also detected within PBL. Thus, EBV coinfection and recombination are consistent findings in persons with HLP regardless of immune status. Virally mediated determinants may be important features of EBV pathogenesis.