Dissolving polymer microneedle patches for influenza vaccination.
Dissolving polymer microneedle patches for influenza vaccination.
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作者：
流感预防将受益于一种疫苗接种方法，这种方法能够简化后勤工作，提高免疫原性，而不会造成皮下注射针头带来的危险。在这里，我们介绍了用于流感疫苗接种的溶解微针贴片，使用一种简单的贴片为基础的系统，靶向递送到皮肤的抗原呈递细胞。微针是用生物相容性聚合物包封灭活流感病毒疫苗制成的，可以在几分钟内插入并溶解在皮肤中。微针疫苗在小鼠中产生了强大的抗体和细胞免疫反应，提供了对致命挑战的完全保护。与传统的肌肉注射相比，微针疫苗接种可更有效地清除肺部病毒，并增强攻击后的细胞召回反应。这些结果表明，溶解微针贴片可以提供一种更简单、更安全的疫苗接种新技术，提高免疫原性，有助于提高疫苗接种覆盖率。
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here, we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin’s antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a novel technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.