BRAIN CHANGES IN EXPERIMENTAL CHRONIC HYPOXIA
BRAIN CHANGES IN EXPERIMENTAL CHRONIC HYPOXIA
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DOI：
10.1016/s0232-1513(11)80067-8
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
HAMDORF, G
中科院分区：
文献类型：
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作者：
CERVOSNAVARRO, J;SAMPAOLO, S;HAMDORF, G
建立常压缺氧模型，成年母猫暴露于逐渐减少的氧气量（21、15、10、8、7和5体积%）。在320天内。大脑和小脑的血流以及血流对pCO2变化的反应都受到抑制。这些下降在小脑中更为严重。氧代谢率也受到抑制，浦肯野细胞数量明显减少。小脑上、中、下回均有不同程度的损害。全脑微血管增生。
A model of normobaric hypoxia was developed in which adult female cats were exposed to decreasing amounts of oxygen (21, 15, 10, 8, 7, and 5 vol.%) over a period of 320 days. Blood flow as well as the blood flow responses to changes of pCO2 were depressed in both cerebrum and cerebellum. These decreases were more severe in the cerebellum. The metabolic rate for oxygen was also depressed.A decrease in the Purkinje cell number was evident. A different degree of damage was observed in the top, the intermediate and the bottom region of the cerebellar gyri. Microvascular proliferation occurred in the whole brain.