The genetic epidemiology of schizophrenia in a Finnish twin cohort -: A population-based modeling study
The genetic epidemiology of schizophrenia in a Finnish twin cohort -: A population-based modeling study
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DOI：
10.1001/archpsyc.55.1.67
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发表时间：
1998-01-01
影响因子：
--
通讯作者：
Koskenvuo, M
中科院分区：
文献类型：
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作者：
Cannon, TD;Kaprio, J;Koskenvuo, M
背景资料：精神分裂症的遗传度的大小仍然存在争议，部分原因是仅从指数双胞胎对获得的估计值的局限性。我们应用结构方程模型在双胞胎总人口中确定精神分裂症的遗传和环境贡献的重要性和程度。方法：全单合子（1180对男性和1315对女性）和同性双卵（2765对男性和2613对女性）对1940年至1957年在芬兰出生的双胞胎进行了非器质性精神病性障碍诊断的筛查，这些诊断记录在住院或门诊基础上，结果：精神分裂症的终生患病率为2.0%，男性患病率（2.2%）略高于女性（1.8%）。模型拟合表明，83%的变异是由于加性遗传因素，其余17%是由于独特的环境因素。性别限制模型显示，没有证据表明性别特异性遗传效应和遗传力的大小没有性别差异。一个多阈值模型，将情感和其他精神病之间的精神分裂症和没有diagnosis的表型intermediate被rejected.Conclusions：在一个以人口为基础的双胞胎研究精神分裂症，遗传率估计为83%，其余的变异归因于环境因素的责任不共享共同的co-twins。尽管使用通过治疗联系确定的诊断有明显的局限性，但本研究中的遗传度估计值与最近使用DSM-III或更高标准的标准化应用的指数对研究中报告的结果几乎相同。
Background: The magnitude of heritability of schizophrenia remains controversial, due in part to limitations of estimates derived from index twin pairs exclusively. We applied structural equation modeling in a total population of twins to determine the significance and magnitudes of the genetic and environmental contributions to schizophrenia.Methods: All monozygotic (1180 male and 1315 female pairs) and same-sex dizygotic (2765 male and 2613 female pairs) twins born from 1940 to 1957 in Finland were screened for nonorganic psychotic disorder diagnoses as recorded on an inpatient or outpatient basis or from an eligibility review for a disability pension.Results: The lifetime prevalence of schizophrenia was 2.0%, with a marginally higher prevalence in men (2.2%) than women (1.8%). Model fitting indicated that 83% of the variance in liability was due to additive genetic factors, and the remaining 17% was due to unique environmental factors. Sex-limitation modeling revealed no evidence of sex-specific genetic effects and no sex difference in the magnitude of heritability. A multiple threshold model incorporating affective and other psychoses as a phenotype intermediate between schizophrenia and no diagnosis was rejected.Conclusions: In a population-based twin study of schizophrenia, heritability was estimated at 83%, with the remaining variance in liability attributed to environmental factors not shared in common among co-twins. Despite the notable limitation of using diagnoses ascertained through treatment contacts, the heritability estimate in this study is almost identical to those reported in recent studies of index pairs using standardized applications of DSM-III or later criteria.