Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol.
Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol.
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嗜酒 (P) 大鼠持续大量饮酒是由于缺乏对酒精的正常厌恶。
DOI：
10.1093/alcalc/agq020
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Levin,EdwardD
中科院分区：
文献类型：
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作者：
Rezvani,AmirH;Sexton,Hannah;Levin,EdwardD
目的：在这项研究中，我们测试了酒精预处理的影响，随后在远交的Sprague-Dawley和选择性繁殖的酒精偏好（P）rates.Methods：作为预处理，雄性Sprague-Dawley和P大鼠被动口服酒精（1.0 g/kg）或自来水。然后，他们自由选择饮用酒精（5% v/v）或水在他们的家cages，这是测量超过4 weeks.Results：没有酒精预处理，有没有显着的菌株差异，酒精偏好;两种菌株首选5%（v/v）酒精溶液。菌株差异仅在给予酒精预处理的组中明显。这是因为酒精预处理显著降低了Sprague-Dawley大鼠的酒精偏好，使其降至远低于50%的水平，而它并没有改变P大鼠的饮酒行为。在总饮酒量（g/kg/天）中观察到相同的影响。这些影响持续整个4周的study.Conclusions：Sprague-Dawley和P大鼠之间的主要区别是，P大鼠没有表现出正常的厌恶酒精后，强迫暴露于酒精的Sprague-Dawley大鼠显示。高酒精摄入量和偏好的P大鼠的潜在贡献者之一可能是缺乏敏感性，酒精的厌恶作用。
Aims:In this study, we tested the impact of pretreatment with alcohol on subsequent alcohol drinking in outbred Sprague–Dawley and selectively bred alcohol-preferring (P) rats.Methods:As a pretreatment, male Sprague–Dawley and P rats were given a passive oral administration of either alcohol (1.0 g/kg) or tap water. Then, they were given free choice of drinking alcohol (5% v/v) or water in their home cages, which was measured over 4 weeks.Results:Without alcohol pretreatment, there was no significant strain difference in alcohol preference; both strains preferred 5% (v/v) alcohol solution. The strain difference was only apparent in the groups given alcohol pretreatment. This arose from the fact that alcohol pretreatment significantly reduced alcohol preference in the Sprague–Dawley rats to a level well below 50%, while it did not alter drinking behavior in P rats. The same effects were seen with total alcohol consumption (g/kg/day). These effects persisted throughout the 4 weeks of the study.Conclusions:The principal difference between the Sprague–Dawley and P rats was that the P rats did not show the normal aversion to alcohol after forced exposure to alcohol that the Sprague–Dawley rats showed. One of the potential contributors to high alcohol intake and preference in P rats may be lack of sensitivity to aversive effects of alcohol.