Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152.
Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152.
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DOI：
10.1039/c6ob00840b
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发表时间：
2016-07
影响因子：
3.2
通讯作者：
John D. Sidda;Vincent Poon;Lijiang Song;Weishan Wang;Keqian Yang;C. Corre
中科院分区：
文献类型：
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作者：
John D. Sidda;Vincent Poon;Lijiang Song;Weishan Wang;Keqian Yang;C. Corre
γ-丁内酮(GBL)是控制链霉菌中抗生素生产的信号分子。基因工程菌株天蓝色链霉菌M1152被发现能够过量生产GBL SCB1-3和五种名为SCB4-8的新型GBL。用同位素标记的前体进行的掺入实验证实了SCB1-3的化学结构，并建立了SCB4-8的化学结构。
Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1-3 as well as five novel GBLs named SCB4-8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1-3 and established those of SCB4-8.