Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes.
Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes.
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DOI：
10.1016/j.semcdb.2015.06.003
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发表时间：
2015-06
影响因子：
7.3
通讯作者：
Mullins MC
中科院分区：
文献类型：
--
作者：
Tuazon FB;Mullins MC
脊椎动物的身体计划是通过形成前后(AP)和背腹轴(DV)轴的精确时空协调形态原信号通路来建立的。沿着AP轴的模式是由Wnt、成纤维细胞生长因子(FGF)、Nodal和维甲酸(RA)的后化信号引导的，而沿DV轴的模式是由骨形态发生蛋白(BMP)的内化信号指导的。本文就WNT、成纤维细胞生长因子、RA和BMP如何在AP和DV细胞发育早期形成不同的命运，以及它们的信号机制如何协调以同时形成AP和DV组织的研究进展作一综述。
The vertebrate body plan is established through the precise spatiotemporal coordination morphogen signaling pathways that pattern the anteroposterior (AP) and dorsoventral (DV) axes. Patterning along the AP axis is directed by posteriorizing signals Wnt, fibroblast growth factor (FGF), Nodal, and retinoic acid (RA), while patterning along the DV axis is directed by bone morphogenetic proteins (BMP) ventralizing signals. This review addresses the current understanding of how Wnt, FGF, RA and BMP pattern distinct AP and DV cell fates during early development and how their signaling mechanisms are coordinated to concomitantly pattern AP and DV tissues.