The effects of bromocriptine treatment during early pregnancy on postpartum maternal behaviors in rats.
The effects of bromocriptine treatment during early pregnancy on postpartum maternal behaviors in rats.
复制标题
妊娠早期溴隐亭治疗对大鼠产后母性行为的影响。
DOI：
10.1002/dev.21224
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发表时间：
2014
影响因子：
2.2
通讯作者：
Bridges,RobertS
中科院分区：
文献类型：
--
作者：
Price,AnyaK;Bridges,RobertS
催乳素是脑垂体前叶的一种激素，参与启动母性行为、缓解产后焦虑和刺激催乳作用。溴隐亭是一种多巴胺D2受体激动剂，可抑制催乳素分泌。溴隐亭给药抑制小鼠的产后母体行为（幼仔取回），并在高架十字迷宫中引起焦虑升高[Larsen & Gravity（2010）.内分泌学151（8）：3805-3814]。在其他物种中是否存在类似的影响尚不清楚。本研究探讨催乳素在大鼠妊娠早期可能参与母亲的行为和焦虑。溴隐亭给药的第2-4天怀孕导致受损的产后母亲的行为在一个新的环境在哺乳早期。然而，与对照组相比，溴隐亭治疗受试者在高架十字迷宫中未表现出产后焦虑增加。这些发现支持了小鼠的工作，即妊娠早期的溴隐亭治疗阻碍了产后母亲的护理，并表明妊娠早期的激素状态更广泛地影响了其他哺乳动物的产后行为。© 2014 Wiley Periodicals，Inc. Dev Psychobiol 56：1431-1437，2014.
Prolactin, a hormone of the anterior pituitary, is involved in initiating maternal behavior, alleviating postpartum anxiety, and stimulating lactogenesis. Bromocriptine, a dopamine D2 receptor agonist, inhibits prolactin secretion. Bromocriptine administration represses postpartum maternal behaviors (pup retrieval) in mice, and causes elevated anxiety in the elevated plus maze [Larsen & Grattan (2010). Endocrinology 151(8): 3805–3814]. Whether similar effects exist in other species is unknown. The present study examined the possible involvement of prolactin during early gestation on maternal behavior and anxiety in rats. Bromocriptine given on days 2–4 of pregnancy resulted in impaired postpartum maternal behaviors in a novel environment during early lactation. However, compared to controls, bromocriptine‐treated subjects did not exhibit increased postpartum anxiety in the elevated plus maze. These findings support work in mice that bromocriptine treatment during early gestation impedes postpartum maternal care, and indicate that early gestational hormonal status affects postpartum behavior more broadly in other mammals. © 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1431–1437, 2014.