Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue
Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue
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DOI：
10.1364/ao.38.005480
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发表时间：
1999-09-01
期刊：
影响因子：
1.9
通讯作者：
Paulsen, KD
中科院分区：
文献类型：
--
作者：
McBride, TO;Pogue, BW;Paulsen, KD
近红外（NIR）光谱扩散断层扫描已被用来映射的血红蛋白浓度和血红蛋白氧饱和度定量在组织样幻影，并确定平均值在体内。进行了一系列的体模校准，以实现在多个光学波长的吸收和减少的散射系数的定量准确的图像。将最小二乘拟合应用于多个NIR波长处的吸收系数图像，以获得浓度和血红蛋白氧饱和度的血红蛋白图像。不同的血红蛋白浓度和氧饱和度的高度散射介质内的对象进行本地化和成像到其实际值的15%以内。对两名女性志愿者的乳腺组织进行了平均血红蛋白浓度和氧饱和度的活体测量。潜在的应用乳腺肿瘤的诊断进行了讨论。(C)1999年美国光学学会。
Near-infrared (NIR) spectroscopic diffuse tomography has been used to map the hemoglobin concentration and the hemoglobin oxygen saturation quantitatively in tissuelike phantoms and to determine average values in vivo. A series of phantom calibrations were performed to achieve quantitatively accurate images of the absorption and the reduced scattering coefficients at multiple optical wavelengths. A least-squares fit was applied to absorption-coefficient images at multiple NIR wavelengths to obtain hemoglobin images of the concentration and the hemoglobin oxygen saturation. Objects of varying hemoglobin concentration and oxygen saturation within highly scattering media were localized and imaged to within 15% of their actual values. The average hemoglobin concentration and oxygen saturation of breast tissue was measured in vivo for two women volunteers. The potential application for the diagnosis of breast tumors is discussed. (C) 1999 Optical Society of America.