Aggressive oligodendroglioma predicted by chromosome 10 restriction fragment length polymorphism analysis. Case study.
Aggressive oligodendroglioma predicted by chromosome 10 restriction fragment length polymorphism analysis. Case study.
复制标题
通过 10 号染色体限制性片段长度多态性分析预测侵袭性少突胶质细胞瘤。
DOI：
10.1007/bf01050260
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发表时间：
1993
影响因子：
3.9
通讯作者：
Darras,BT
中科院分区：
文献类型：
--
作者：
Wu,JK;Folkerth,RD;Ye,Z;Darras,BT
少突胶质细胞瘤是惰性脑肿瘤，术后平均生存期约为 5 年。然而，术后生存率范围很广，表明这些肿瘤的生物学行为具有异质性。我们利用限制性片段长度多态性 (RFLP) 分析，研究了一例 10 号染色体序列丢失的少突胶质细胞瘤，这一发现仅在多形性胶质母细胞瘤和间变性星形细胞瘤中报道过。初次手术后四个半月，患者复发肿瘤，具有多形性胶质母细胞瘤的典型放射学和病理学特征。即使在缺乏公认的退行性变性组织病理学特征的情况下，少突胶质细胞瘤中 10 号染色体等位基因的丢失也可能预示着侵袭性生物学行为，并且可能使我们能够为这组患者选择更合适的治疗方法。
Oligodendrogliomas are indolent brain tumors with mean postoperative survival of about 5 years. However, the range of postoperative survivals is wide, suggesting that these tumors are heterogeneous in their biologic behavior. Using restriction fragment length polymorphism (RFLP) analysis, we studied a case of an oligodendroglioma with loss of chromosome 10 sequences, a finding that has only been reported in glioblastoma multiforme and anaplastic astrocytomas. Four and a half months after the initial surgery the patient returned with a recurrent tumor having classic radiologic and pathologic features of glioblastoma multiforme. Loss of chromosome 10 alleles in oligodendroglioma may be predictive of aggressive biologic behavior, even in the absence of recognized histopathologic characteristics of anaplasia, and may enable us to select more appropriate treatments for this group of patients.