IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex
IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex
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DOI：
10.1093/nar/gkg070
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Marsh, SGE
中科院分区：
文献类型：
--
作者：
Robinson, J;Waller, MJ;Marsh, SGE
在过去的四年里，http://www.ebi.ac.uk/imgt/hla)数据库为世界卫生组织人类白细胞抗原系统因素命名委员会命名的等位基因序列提供了一个集中的储存库。自最初发布以来，该数据库已经发展壮大，并成为研究人类主要组织相容性复合体序列的主要信息来源。最初发布的数据库包含的工具数量有限。由于我们用户的反馈和人类白细胞抗原的发展，我们已经能够提供新的工具和设施。人类白细胞抗原的序列也被扩展到包括内含子序列和比对中的3‘和5’非翻译区，还包括了新的基因，如MICA。该数据库(http://www.ebi.ac.uk/imgt/mhc))于2002年3月发布，为其他物种提供了类似的资源。IMGT/MHC的第一次发布包含了非人类灵长类动物(类人猿、新旧大陆猴子)、犬类和猫科动物的序列。不久将增加更多的物种，该数据库的目标是成为非人类序列的MHC数据的主要来源。
The IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System for the past four years. Since its initial release the database has grown and is the primary source of information for the study of sequences of the human major histocompatibilty complex. The initial release of the database contained a limited number of tools. As a result of feedback from our users and developments in HLA we have been able to provide new tools and facilities. The HLA sequences have also been extended to include intron sequences and the 3' and 5' untranslated regions in the alignments and also the inclusion of new genes such as MICA. The IMGT/MHC database (http://www.ebi.ac.uk/imgt/mhc) was released in March 2002 to provide a similar resource for other species. The first release of IMGT/MHC contains the sequences of non-human primates (apes, new and old world monkeys), canines and feline sequences. Further species will be added shortly and the database aims to become the primary source of MHC data for non-human sequences.