Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors
Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors
复制标题
DOI：
10.1097/rlu.0b013e3182177407
复制
发表时间：
2011-11-01
影响因子：
10.6
通讯作者：
Ozaki, Toshifumi
中科院分区：
文献类型：
--
作者：
Kawakami, Naoaki;Kunisada, Toshiyuki;Ozaki, Toshifumi
背景资料：方法：1995年4月至2005年12月，对192例软组织肿瘤患者（恶性85例，良性107例）在治疗前进行201-Tl放射造影检查。同位素摄取被用作肿瘤背景比（TBR）的代表。使用Mann-Whitney U和卡方检验评估TBR在早期和延迟成像上的准确性。恶性和良性软组织肿瘤的早期和延迟成像的平均TBR有统计学显著差异（124% +/- 109% vs. 22% +/-42%和82% +/- 83% vs. 12% +/-25%，P < 0.0001）。20%的TBR临界值表明早期和延迟成像的恶性概率（82%敏感性和77%特异性; 82%敏感性和84%特异性，P < 0.0001）。高分化的脂肪肉瘤显示低的同位素积聚，而色素沉着绒毛结节性滑膜炎和腱鞘巨细胞瘤显示高的同位素积聚。结论：铊-201放射成像可以区分恶性和良性肿瘤具有相对较高的准确性。除了低级别脂肪肉瘤和局部侵袭性良性肿瘤外，201-Tl放射造影可能是鉴别恶性和良性软组织肿瘤的有效诊断方法。
Background: The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors.Methods: Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and chi(2) tests.Results: There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124% +/- 109% vs. 22% +/- 42%, and 82% +/- 83% vs. 12% +/- 25%, P < 0.0001). A TBR cutoff of 20% indicated the probability of malignancy on early and delayed imaging (82% sensitivity and 77% specificity; 82% sensitivity and 84% specificity, P < 0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation.Conclusions: Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.