The role of fat depletion in the biological benefits of caloric restriction
The role of fat depletion in the biological benefits of caloric restriction
复制标题
DOI：
10.1093/jn/131.3.903s
复制
发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Gabriely, I
中科院分区：
文献类型：
--
作者：
Barzilai, N;Gabriely, I
衰老生物学中最有力的观察之一是热量限制（CR）延长了各种物种的寿命。尽管CR导致脂肪量大幅减少，但认为脂肪在延长寿命中的作用极小。事实上，在肥胖和糖尿病领域，脂肪的量直接涉及代谢的后果。由于脂肪是一种巨大的内分泌组织，它的一些作用最近已经被修正。CR的许多全身效应现在可以通过与脂肪中产生的肽、细胞因子、补体因子和底物的血浆水平降低相关的慢性效应来解释。CR对神经内分泌系统的大部分益处以及与葡萄糖稳态改善相关的益处可归因于脂肪细胞及其产物的减少。如果CR的所有或大部分延长寿命的益处可以归因于脂肪储存减少，则可以探索和操纵特定候选底物和蛋白质的表达，以寻找调节预期寿命的最强大的脂肪依赖性信号。
One of the most robust observations in the biology of aging is that caloric restriction (CR) extends life in a variety of species. Although CR results in substantial decrease in fat mass, the role of fat in life extension was considered minimal. Indeed, in the fields of obesity and diabetes, the amount of fat has been directly implicated in the metabolic consequences. Since it became apparent that fat is a massive endocrine tissue, some of its roles have been recently revised. Many of the systemic effects of CR can now be explained by the chronic effects related to decreased plasma levels of peptides, cytokines, complement factors and substrates that are produced in fat. Most of the benefits of CR on the neuroendocrine system and those related to the improvement in glucose homeostasis can be attributed to a decrease in adipose cells and their products. If all or most of the life-extending benefits of CR can be attributed to decreased fat stores, the expression of specific candidate substrates and proteins may be explored and manipulated in searching for the most powerful adipose-dependent signals that modulate life expectancy.