Thrice-weekly supervised dosing with the combination buprenorphine-naloxone tablet is preferred to daily supervised dosing by opioid-dependent humans
Thrice-weekly supervised dosing with the combination buprenorphine-naloxone tablet is preferred to daily supervised dosing by opioid-dependent humans
复制标题
DOI：
10.1016/s0376-8716(00)00141-1
复制
发表时间：
2001-01-01
影响因子：
4.2
通讯作者：
Mikulich, SK
中科院分区：
文献类型：
--
作者：
Amass, L;Kamien, JB;Mikulich, SK
将8 mg丁丙诺啡与2 mg纳洛酮组合的丁丙诺啡舌下片剂制剂用于可能采用少于每日给药策略和/或基于处方的分配的环境中。本研究确定了使用复方片剂的每日和每周3天监督给药方案的患者偏好和临床结局。完成16天基线的24例阿片类药物依赖受试者进入门诊三重交叉试验。将每日给药21天与每周3天监督给药的两个不同的21天阶段进行比较：每周3天门诊给药方案和每周3天带回家给药方案，其中在门诊访视之间的日期向受试者提供片剂，供其在家服用。13名患者完成了研究。每周3天给药方案下摄入的剂量显著更多。非法药物的使用在不同条件下没有差异，45%的尿液样本对非法阿片类药物检测呈阳性。受试者“喜欢”每周3天的时间表比每天的时间表，和感觉“好”的评级更高的3天带回家，而不是3天的诊所条件。几乎所有受试者（91%）将3天带回家作为最首选的时间表。总体而言，减少门诊就诊率改善了用药依从性，提高了客户满意度，而不影响非法药物使用。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
A sublingual tablet formulation of buprenorphine combining 8 mg of buprenorphine with 2 mg of naloxone is being targeted for use in settings where less than daily dosing strategies and/or prescription-based dispensing will likely be employed. This study determined patient preferences for, and clinical outcomes during, daily and 3-day per week supervised dosing schedules using the combination tablet. Twenty-four opioid-dependent subjects completing a 16-day baseline entered an outpatient triple crossover trial. Twenty-one days of daily dosing were compared to two different 21-day periods of 3-day per week supervised dosing: a 3-day per week clinic schedule and a 3-day per week take-home schedule in which tablets were provided to subjects to take at home on days between clinic visits. Thirteen patients completed the study. Significantly more doses were ingested under the 3-day per week schedules. Illicit drug use did not differ across conditions and 45% of urine samples tested positive for illicit opioids. Subjects 'liked' both 3-day per week schedules more than the daily schedule, and ratings of feeling 'good' were higher for the 3-day take-home as opposed to 3-day clinic condition. Almost all subjects (91%) rated 3-day take-home as the most preferred schedule. Overall, reducing clinic attendance improved medication compliance and increased client satisfaction without impacting illicit drug use. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.