Local functional connectivity alterations in schizophrenia, bipolar disorder, and major depressive disorder
Local functional connectivity alterations in schizophrenia, bipolar disorder, and major depressive disorder
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精神分裂症、双相情感障碍和重度抑郁症的局部功能连接改变
DOI：
10.1016/j.jad.2018.04.069
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发表时间：
2018
影响因子：
6.6
通讯作者：
Wang Fei
中科院分区：
文献类型：
--
作者：
Wei Yange;Chang Miao;Fay Womer Y;Zhou Qian;Yin Zhiyang;Wei Shengnan;Zhou Yifang;Jiang Xiaowei;Yao Xudong;Duan Jia;Xu Ke;Zuo Xi Nian;Tang Yanqing;Wang Fei
背景局部功能连接（FC）表示局部或短距离的功能相互作用，可作为研究人脑连接组的神经影像标记。局部 FC 改变表明整个大脑网络的局部功能平衡被破坏，并且越来越多地与精神分裂症 (SZ)、双相情感障碍 (BD) 和重度抑郁症 (MDD) 相关。方法我们的目的是检查 SZ、BD 和 MDD 局部 FC 的异同。总共 537 名参与者（SZ，126 名；BD，97 名；MDD，126 名；健康对照，188 名）在单个部位完成了静息态功能磁共振成像。计算并比较 SZ、BD 和 MDD 静息状态下的局部 FC。结果在双侧眶额皮质 (OFC) 和左侧 OFC 延伸至壳核的附加区域内，SZ、BD 和 MDD 的局部 FC 增加，初级视觉、听觉和运动皮质、右侧辅助运动区和双侧丘脑的局部 FC 减少。改变的程度存在梯度，例如 SZ>BD>MDD。局限性这项横断面研究不能考虑药物和其他临床变量。结论这些发现表明 SZ、BD 和 MDD 中的网络整合和分离之间的平衡被破坏，包括通过 OFC 中局部 FC 的增加而过度整合，以及随着初级感觉皮层和丘脑中局部 FC 的减弱而减少神经处理的分离。 SZ、BD 和 MDD 共有的局部 FC 异常可能为这些疾病潜在的生物学机制提供新的线索。
BackgroundLocal functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD).MethodsWe aim to examine the similarities and differences in the local FC across SZ, BD, and MDD. In total, 537 participants (SZ, 126; BD, 97; MDD, 126; and healthy controls, 188) completed resting-state functional magnetic resonance imaging at a single site. The local FC at resting state was calculated and compared across SZ, BD, and MDD.ResultsThe local FC increased across SZ, BD, and MDD within the bilateral orbital frontal cortex (OFC) and additional region in the left OFC extending to putamen and decreased in the primary visual, auditory, and motor cortices, right supplemental motor area, and bilateral thalami. There was a gradient in the extent of alterations such that SZ > BD > MDD.LimitationsThis cross-sectional study cannot consider medications and other clinical variables.ConclusionsThese findings indicate a disrupted balance between network integration and segregation in SZ, BD, and MDD, including over-integration via increased local FC in the OFC and diminished segregation of neural processing with the weakening of the local FC in the primary sensory cortices and thalamus. The shared local FC abnormalities across SZ, BD, and MDD may shed new light on the potential biological mechanisms underlying these disorders.