NFAT and NF-κB factors—the distant relatives
NFAT and NF-κB factors—the distant relatives
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DOI：
10.1016/j.biocel.2003.07.002
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发表时间：
2004-07
期刊：
影响因子：
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通讯作者：
E. Serfling;F. Berberich-Siebelt;A. Avots;S. Chuvpilo;S. Klein-Hessling;M. Jha;E. Kondo;P. Pagel;Jan Schulze-Luehrmann;A. Palmetshofer
中科院分区：
文献类型：
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作者：
E. Serfling;F. Berberich-Siebelt;A. Avots;S. Chuvpilo;S. Klein-Hessling;M. Jha;E. Kondo;P. Pagel;Jan Schulze-Luehrmann;A. Palmetshofer
NFAT和NF-κB蛋白是转录因子超家族的成员，其活性在淋巴细胞的激活、增殖和凋亡中起着至关重要的作用。这两种类型的因子都具有许多特性，包括相似的DNA结合结构域和抗原刺激下的快速核易位。NF-κ b控制先天和适应性免疫反应，而NFAT控制适应性免疫系统，这与NFAT家族的出现并行。然而，nfat和NF-κ b在功能上有显著差异。虽然nfat支持T细胞和B细胞的活化诱导细胞死亡（AICD），但NF-κB蛋白经常对淋巴细胞和其他细胞发挥强大的抗凋亡作用。虽然NF-κ b的抗凋亡活性有助于其致癌能力，但促凋亡活性有利于nfat在淋巴样细胞中作为肿瘤抑制因子。
NFAT and NF-κB proteins are members of a superfamily of transcription factors whose activity plays a crucial role in the activation, proliferation and apoptosis of lymphocytes. Both types of factors share a number of properties, including similar DNA binding domains and rapid nuclear translocation upon antigenic stimulation. While NF-κBs control both innate and adaptive immune responses, NFATs control the adaptive immune system which emerged—in parallel with the appearance of the NFAT family—in jawed fish. However, NFATs and NF-κBs differ remarkably in their function. Whereas NFATs support activation-induced cell death (AICD) of T and B cells, NF-κB proteins frequently exert a strong anti-apoptotic effect on lymphocytes and other cells. While the anti-apoptotic activity of NF-κBs contributes to their oncogenic capacity, the pro-apoptotic activity favors NFATs as tumor suppressors in lymphoid cells.