Follicle dynamics during ovarian ageing
Follicle dynamics during ovarian ageing
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DOI：
10.1016/s0303-7207(99)00238-5
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发表时间：
2000-05-25
影响因子：
4.1
通讯作者：
Faddy, MJ
中科院分区：
文献类型：
--
作者：
Faddy, MJ
人类卵巢在出生时就具有固定数量的原始卵泡，由于闭锁和排卵的补充，原始卵泡在一生中稳步减少。这种下降的模式不是指数的，而是更多的双指数，对应于记录的卵泡总数随年龄的“断棒”回归。这样的模型意味着在38岁时卵泡损失的指数率突然变化，因此在生物学上是相当不可信的。一个更精确的模型，其卵泡损失的指数率在整个生命过程中逐渐变化，也描述了卵泡数量下降的数据，但除此之外，还导致了绝经年龄的分布，对应于卵泡数量下降到临界阈值以下，这与美国妇女绝经年龄的独立数据非常吻合。当卵泡分为静止和生长阶段时，发现随着卵巢年龄的增长，卵泡发育过程中的任何变化主要与小的静止卵泡有关，而不是较大的生长卵泡。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
The human ovary is endowed at birth with a fixed number of primordial follicles which steadily declines throughout life as a result of atresia and recruitment towards ovulation. The pattern of this decline is not exponential, but more bi-exponential corresponding to a 'broken-stick' regression of logged total numbers of follicles against age. Such a model implies an abrupt change in the exponential rate of follicle loss at age 38 years, and is thus rather implausible biologically. A more refined model with an exponential rate of follicle loss that changes gradually throughout life also describes the data on declining follicle numbers but in addition leads to a distribution of age at menopause, corresponding to follicle numbers falling below a critical threshold, that shows quite remarkable agreement with independent data on menopausal ages of American women. When the follicles are classified into resting and growing stages, it is found that any changes in the consequent process of follicle development as the ovary ages relate mainly to the small resting follicles and not the larger growing ones. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.