Diabetes, insulin resistance, and the metabolic syndrome in patients with acute myocardial infarction without previously known diabetes
Diabetes, insulin resistance, and the metabolic syndrome in patients with acute myocardial infarction without previously known diabetes
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DOI：
10.2337/diacare.26.10.2770
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发表时间：
2003-10-01
期刊：
影响因子：
16.2
通讯作者：
Malmberg, K
中科院分区：
文献类型：
--
作者：
Tenerz, Å;Norhammar, A;Malmberg, K
目的-糖尿病患者急性心肌梗死（AMI）的发病率增加.根据口服葡萄糖耐量试验（OGTT），40-45%的AMI患者患有糖尿病。本研究的目的是表征的葡萄糖代谢概况的B L IC perturn在ON患者与AMI没有已知的糖尿病，看看是否持续glucometa是可预测的在医院阶段的diseases.RESEARCH设计和方法-共145例AMI和以前没有糖尿病的诊断进行OGTT在出院和3个月后。根据3个月后的OGTT，他们被定义为正常糖耐量（NGT; It = 50）、糖耐量受损（IGT; n = 59）或糖尿病（n = 36）。代谢综合征的组成部分，包括胰岛素抵抗评估的稳态模型评估（HOMA-IR），recorded.RESULTS -AMI患者从出院到随访的胰岛素抵抗没有变化。OGTT和/或在出院时摄入75 g葡萄糖后60分钟采集的单次血糖（BG-60）是随访时OGTT结果的预测因子。BG-60的截止值为8.6 mmol/l，70%的患者在3个月后被正确预测为属于NGT组或IGT/糖尿病组。年龄，体重指数，抗高血压治疗，HbA（1c）空腹血糖，血脂，胰岛素，胰岛素原，HOMA-IR，纤溶酶原激活物抑制剂I没有增加预测power.CONCLUSIONS -AMI患者和以前没有诊断糖尿病没有变化，胰岛素抵抗从出院到3个月的随访。OGTT或在出院时进行的单次BG-60预测IGT或糖尿病的诊断3个月。然后
OBJECTIVE - individuals with diabetes have an increased morbidity from acute myocardial infarction (AMI). Based on an oral glucose tolerance test (OGTT), 40-45% of patients with AMI have diabetes. The objective of this study was to characterize the glucometabolic profile of b l ic pertur at ons patients with AMI without known diabetes and to see if sustained glucometa are predictable during the hospital phase of the disease.RESEARCH DESIGN AND METHODS - A total of 145 patients with AMI and no previous diagnosis of diabetes were subjected to an OGTT at hospital discharge and 3 months thereafter. Based on the OGTT after 3 months, they were defined as having normal glucose tolerance (NGT; It = 50), impaired glucose tolerance (IGT; n = 59), or diabetes (n = 36). Components of the metabolic syndrome, including insulin resistance assessed by homeostasis model assessment (HOMA-IR), were recorded.RESULTS - Patients with AMI had no changes in insulin resistance from hospital discharge to follow-up. An OGTT and/or a Single blood glucose taken 60 min (BG-60) after ingestion of 75 g glucose at hospital discharge were predictors of the outcome of the OGTT at follow-up With a cutoff value for BG-60 of 8.6 mmol/l, 70% of the patients were correctly predicted as either belonging to the NGT group or the IGT/diabetes group after 3 months. Age, BMI, antihypertensive treatment, HbA(1c) fasting blood glucose, blood lipids, insulin, proinsulin, HOMA-IR, and plasminogen activator inhibitor I did not add predictive power.CONCLUSIONS - Patients with AMI and no previous diagnosis of diabetes have no changes in insulin resistance from hospital discharge to a 3-month follow-up. An OGTT or a single BG-60 performed at hospital discharge predicts the diagnosis of IGT or diabetes 3 months. thereafter.