Total synthesis of methyl protodioscin: A potent agent with antitumor activity
Total synthesis of methyl protodioscin: A potent agent with antitumor activity
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DOI：
10.1021/jo020683w
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发表时间：
2003-05-02
影响因子：
3.6
通讯作者：
Yang, Z
中科院分区：
文献类型：
--
作者：
Cheng, MS;Wang, QL;Yang, Z
甲基原薯蓣皂苷 (1)，也称为 3-O-[α-L-吡喃鼠李糖基-(1-->2)-{α-L-吡喃鼠李糖基-(1-->4) }-β-D-吡喃葡萄糖基]-26-O-[β-D-吡喃葡萄糖基]-22-甲氧基-25(R)-furost-5-ene-3β,26-二醇，首次由薯蓣皂苷元通过九个步骤合成，总产率为7.8%。
Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-{alpha-L-rhamnopyranosyl-(1-->4) }-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.