Cyclotron production of 64Cu by deuteron irradiation of 64Zn
Cyclotron production of 64Cu by deuteron irradiation of 64Zn
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DOI：
10.1016/j.apradiso.2005.12.021
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发表时间：
2006-09-01
影响因子：
1.6
通讯作者：
Gibson, N.
中科院分区：
文献类型：
--
作者：
Abbas, K.;Kozempel, J.;Gibson, N.
短寿命（12.7 h半衰期）的Cu-64放射性同位素既是β（+）发射体又是β（-）发射体。这种特性使得64 Cu成为一种有前途的新型医学应用候选者，因为它可以同时用于放射性标记生物分子的治疗应用和PET诊断。继以前的工作，Cu-64生产的天然锌的氘照射，我们在这里报告的生产这种放射性同位素的氘照射富集Zn-64。此外，还测量了在该过程中同时产生的其他放射性同位素如（CU）-C-61、（CU）-C-67、Zn-65、Zn-69 m、Ga-66和Ga-67的产率。蒸发程序ALICE-91和传输程序SRIM 2003分别用于确定激发函数和阻止本领。在计算天然和富集Zn靶时，考虑了产生上述放射性同位素的所有核反应。实验和计算的产率被证明是在合理的协议。这项工作是在欧洲联盟委员会联合研究中心健康和消费者保护研究所的Scanditronix MC-40回旋加速器（意大利伊斯普拉）进行的。用19.5 MeV的氘进行辐照，这是MC-40回旋加速器可获得的最大氘能量。(c)2006爱思唯尔有限公司保留所有权利。
The short-lived (12.7 h half_life) Cu-64 radioisotope is both a beta(+) and a beta(-) emitter. This property makes 64Cu a promising candidate for novel medical applications, since it can be used simultaneously for therapeutic application of radiolabelled biomolecules and for diagnosis with PET. Following previous work on Cu-64 production by deuteron irradiation of natural zinc, we report here the production of this radioisotope by deuteron irradiation of enriched Zn-64. In addition, yields of other radioisotopes such as (CU)-C-61, (CU)-C-67, Zn-65, Zn-69m, Ga-66 and Ga-67, which were co-produced in this process, were also measured. The evaporation code ALICE-91 and the transport code SRIM 2003 were used to determine the excitation functions and the stopping power, respectively. All the nuclear reactions yielding the above-mentioned radioisotopes were taken into account in the calculations both for the natural and enriched Zn targets. The experimental and calculated yields were shown to be in reasonable agreement. The work was carried out at the Scanditronix MC-40 Cyclotron of the Institute for Health and Consumer Protection of the Joint Research Centre of the European Commission (Ispra site, Italy). The irradiations were carried out with 19.5 MeV deuterons, the maximum deuteron energy obtainable with the MC-40 cyclotron. (c) 2006 Elsevier Ltd. All rights reserved.