Asebia, a Mutation Affecting Sebaceous Glands, Mouse
Asebia, a Mutation Affecting Sebaceous Glands, Mouse
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Asebia，一种影响皮脂腺的突变，小鼠
DOI：
10.1007/978-3-642-83749-4_36
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Sundberg
中科院分区：
文献类型：
--
作者：
J. Compton;R. Dunstan;J. Sundberg
携带asebia突变ab或ab J的纯合子小鼠的特征为皮脂腺缺陷和其他皮肤异常（ab：Gates and Karasek 1965; Josefowicz and哈代1978 a; ab J：Pennycuik et al. 1986）。在7日龄时，纯合子asebic小鼠显示毛发生长受损。脱发的严重程度随着连续的毛发周期而增加，最终仅存在分散的毛发。细小的表皮鳞屑通常是轻微的，但随着年龄的增长往往会变得更加严重。Asebic小鼠对光敏感并具有眼睑瘙痒，并且粘性渗出物通常会使眼睛结痂（图280）。它们有一种不确定来源的独特气味。这些表型特征的严重程度因遗传背景或两种已知独立突变ab或ab J之间的等位基因差异而异（Pennycuik et al. 1986）。
Homozygous mice carrying the asebia mutation ab or ab J are characterized by defective sebaceous glands and other cutaneous abnormalities (ab: Gates and Karasek 1965; Josefowicz and Hardy 1978a; ab J: Pennycuik et al. 1986). At 7 days of age, homozygous asebic mice display impaired hair growth. Alopecia increases in severity with successive hair cycles, and eventually only scattered hairs are present. The fine epidermal scaling is generally mild but tends to become more severe with aging. Asebic mice are light sensitive and have pruritus of the eyelids, and a sticky exudate typically encrusts the eyes (Fig. 280). They have a distinctive odor of undetermined origin. The severity of these phenotypic features varies, either due to genetic background or to allelic differences between the two known independent mutations, ab or ab J (Pennycuik et al. 1986).