Imaging neuroinflammation in multiple sclerosis using TSPO-PET.
Imaging neuroinflammation in multiple sclerosis using TSPO-PET.
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DOI：
10.1007/s40336-015-0147-6
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发表时间：
2015
影响因子：
2.1
通讯作者：
Rinne JO
中科院分区：
文献类型：
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作者：
Airas L;Rissanen E;Rinne JO
传统的磁共振成像（MRI）技术构成了多发性硬化症（MS）诊断和临床随访的基石。MRI在显示局灶性炎性病变和弥漫性萎缩方面是敏感的。然而，特别是在进展性MS中，斑块外也有越来越广泛的弥漫性病理，通常与小胶质细胞激活和神经变性有关。这是传统MRI无法检测到的。使用18kda转运蛋白（TSPO）结合放射配体的正电子发射断层扫描（PET）成像最近显示出作为检测体内弥漫性病理的工具的希望，并首次允许人们纵向跟踪其发展。越来越明显的是，多发性硬化症越晚期，小胶质细胞的激活就越明显。PET成像允许在分子水平上检测ms相关病理。它有可能测量旨在减少神经变性和神经炎症的新型疾病修饰药物的效果。因此，PET成像可以被纳入未来进展性ms临床试验的设计中，但仍存在与TSPO放射配体质量和后处理方法相关的技术问题，并且来自不同PET中心的研究比较具有挑战性。在这篇综述中，我们总结了支持使用TSPO-PET作为研究MS弥漫性炎症的工具的主要证据。
Conventional MR imaging (MRI) techniques form the cornerstone of multiple sclerosis (MS) diagnostics and clinical follow-up today. MRI is sensitive in demonstrating focal inflammatory lesions and diffuse atrophy. However, especially in progressive MS, there is increasingly widespread diffuse pathology also outside the plaques, often related to microglial activation and neurodegeneration. This cannot be detected using conventional MRI. Positron emission tomography (PET) imaging using 18-kDa translocator protein (TSPO) binding radioligands has recently shown promise as a tool to detect this diffuse pathology in vivo, and for the first time allows one to follow its development longitudinally. It is becoming evident that the more advanced the MS disease is, the more pronounced is microglial activation. PET imaging allows the detection of MS-related pathology at molecular level in vivo. It has potential to enable measurement of effects of new disease-modifying drugs aimed at reducing neurodegeneration and neuroinflammation. PET imaging could thus be included in the design of future clinical trials of progressive MS. There are still technical issues related to the quality of TSPO radioligands and post-processing methodology, and comparison of studies from different PET centres is challenging. In this review, we summarise the main evidence supporting the use of TSPO-PET as a tool to explore the diffuse inflammation in MS.