New insights into cholangiocarcinoma: multiple stems and related cell lineages of origin.
New insights into cholangiocarcinoma: multiple stems and related cell lineages of origin.
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DOI：
10.20524/aog.2017.0209
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发表时间：
2018-01
影响因子：
2.2
通讯作者：
Cardinale V
中科院分区：
文献类型：
--
作者：
Bragazzi MC;Ridola L;Safarikia S;Matteo SD;Costantini D;Nevi L;Cardinale V
胆管癌（CCA）是一组异质性的恶性肿瘤，可发生在胆道系统的任何水平。CCA目前根据其解剖位置分为肝内（iCCA）、门周（pCCA）和远端（dCCA）。值得注意的是，尽管这三种CCA亚型具有共同的特征，但它们也具有重要的肿瘤间和肿瘤内差异，这些差异可能影响其发病机制和结果。CCA的一个独特特征是它表现在肝实质或大的肝内和肝外胆管中，分别由两个不同的干细胞龛提供：Hering管和胆管周围腺。CCA发病机制的复杂性突出了需要一个多学科的，翻译的，系统的方法来处理这种恶性肿瘤。本文综述了CCA的组织形态学、危险因素、分子发病机制和CCA亚型的研究进展。
Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that may develop at any level of the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA) on the basis of its anatomical location. Notably, although these three CCA subtypes have common features, they also have important inter- and intra-tumor differences that can affect their pathogenesis and outcome. A unique feature of CCA is that it manifests in the hepatic parenchyma or large intrahepatic and extrahepatic bile ducts, furnished by two distinct stem cell niches: the canals of Hering and the peribiliary glands, respectively. The complexity of CCA pathogenesis highlights the need for a multidisciplinary, translational, and systemic approach to this malignancy. This review focuses on advances in the knowledge of CCA histomorphology, risk factors, molecular pathogenesis, and subsets of CCA.