Norreticuline and reticuline as possible new agents for hair growth acceleration
Norreticuline and reticuline as possible new agents for hair growth acceleration
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DOI：
10.1248/bpb.20.586
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发表时间：
1997-05-01
影响因子：
2
通讯作者：
Tanahashi, T
中科院分区：
文献类型：
--
作者：
Nakaoji, K;Nayeshiro, H;Tanahashi, T
已显示（S）-去甲牛心果碱和（S）-牛心果碱显著刺激来自鼠毛器的培养细胞的增殖。此外，在培养的毛细胞上发现这些活性，但在培养的角质形成细胞或来自小鼠皮肤的成纤维细胞上没有发现。此外，（S）-去甲牛心果碱显著刺激小鼠毛发再生。这些结果表明，（S）-去甲牛心果碱和（S）-牛心果碱可能对毛器细胞具有特异性活性，并可能用作促进毛发生长的活性化合物。
(S)-Norreticuline and (S)-reticuline have been shown to stimulate the proliferation of cultured cells from the murine hair apparatus significantly. Furthermore, these activities were found on cultured hair cells, but not on cultured keratinocytes or fibroblasts from murine skin. In addition, (S)-norreticuline significantly stimulated mouse hair regrowth. These results suggest that (S)-norreticuline and (S)-reticuline could have specific activities on hair apparatus cells and might be useful as active compounds for accelerating hair growth.