Association of Neighborhood Deprivation With Prostate Cancer and Immune Markers in African American and European American Men.
Association of Neighborhood Deprivation With Prostate Cancer and Immune Markers in African American and European American Men.
复制标题
DOI：
10.1001/jamanetworkopen.2022.51745
复制
发表时间：
2023-01-03
影响因子：
13.8
通讯作者：
Ambs, Stefan
中科院分区：
文献类型：
--
作者：
Pichardo, Margaret S.;Minas, Tsion Zewdu;Pichardo, Catherine M.;Bailey-Whyte, Maeve;Tang, Wei;Dorsey, Tiffany H.;Wooten, William;Ryan, Brid M.;Loffredo, Christopher A.;Ambs, Stefan
本病例对照研究考察了居住在贫困地区的非裔美国人与欧洲裔美国人前列腺癌的发病率和死亡率。在非裔美国人和欧洲裔美国人中，邻里剥夺与前列腺癌结局和循环免疫肿瘤标志物有关吗？在这项对大巴尔的摩地区884名非洲裔美国人和908名欧洲裔美国人进行的病例对照研究中，邻里剥夺与前列腺癌发病率增加、全因和前列腺癌特异性死亡率增加有关，非洲裔美国人的风险更大。邻里剥夺也与肿瘤抑制、趋化和炎症相关的免疫肿瘤途径有关。这项研究的结果表明，贫困的社区环境可能使非洲裔美国人易患致命性前列腺癌，这可能是通过全身免疫环境造成的。邻里变量可能是非裔美国男性前列腺癌负担过重的因素。研究非裔美国人和欧洲裔美国人之间邻里剥夺、循环免疫肿瘤标志物和前列腺癌之间的关系。在2005年1月1日至2016年1月1日期间进行了病例对照研究。参与者包括患有前列腺癌的男性和年龄和种族频率匹配的人群。参与者在巴尔的摩退伍军人事务医学中心和马里兰大学医学中心招募；对照是通过马里兰州机动车管理局数据库获得的。对全国死亡指数进行随访至2020年12月31日，并对2022年2月1日至2022年10月31日进行数据分析。2000年人口普查区邻里剥夺指数作为标准化分数。主要结局包括前列腺癌、全因死亡率和疾病特异性死亡率。次要结果包括国家综合癌症网络风险评分和82种免疫肿瘤学标志物的血清蛋白质组学。参与者包括患有前列腺癌的男性（n = 769: 405名非洲裔美国人，364名欧洲裔美国人）和年龄和种族频率匹配的人群对照（n = 1023: 479名非洲裔美国人，544名欧洲裔美国人）。中位生存随访为9.70年（IQR， 5.77年），219例死亡。在884名非裔美国男性中，招募时的平均（SD）年龄为63.8（7.6）岁；908名欧洲裔美国男性入组时的平均（SD）年龄为66.4（8.1）岁。在个体社会经济地位调整的多变量logistic回归分析中，邻里剥夺与非洲裔美国男性前列腺癌发病率增加55%相关（优势比[OR]， 1.55; 95% CI, 1.33-1.81），但与欧洲裔美国男性前列腺癌发病率无关。在所有男性中，生活在最贫困社区与生活在最贫困社区的男性患病几率高出88% (OR, 1.88; 95% CI, 1.30-2.75)，非裔美国男性患病几率高出约3倍（OR, 3.58; 95% CI, 1.72-7.45），但在欧洲裔美国男性中没有发现关联。在Cox比例风险回归分析中，经社会经济地位调整的邻里剥夺仅在非洲裔美国男性中与全因死亡率增加相关（风险比[HR]， 1.28; 95% CI, 1.08-1.53），而在所有男性中，与转移性疾病和前列腺癌特异性死亡风险增加50%相关（风险比，1.50;95% CI, 1.07-2.09）。在仅限于对照的分析中，邻里剥夺与血清蛋白质组定义的趋化性、炎症和肿瘤免疫抑制活性评分增加有关。这项研究的结果表明，缺乏社区居住可能会增加非洲裔美国男性患前列腺癌的风险和相关死亡率，可能是通过其与全身免疫功能和炎症的关联。
This case-control study examines the incidence and mortality of prostate cancer in African American vs European American men based on residence in deprived areas. Is neighborhood deprivation associated with prostate cancer outcomes and circulating immune oncology markers among African American and European American men? In this case-control study of 884 African American and 908 European American men in the greater Baltimore area, neighborhood deprivation was associated with increased odds of prostate cancer and a higher risk of all-cause and prostate cancer–specific mortality, and a greater risk for African American men. Neighborhood deprivation was also associated with immune-oncology pathways related to tumor suppression, chemotaxis, and inflammation. The findings of this study suggest that a deprived neighborhood milieu may predispose African American men to lethal prostate cancer, potentially through the systemic immune environment. Neighborhood variables may be factors in the excessive burden of prostate cancer among African American men. To examine associations between neighborhood deprivation, circulating immune-oncology markers, and prostate cancer among African American and European American men. A case-control study was conducted between January 1, 2005, and January 1, 2016. Participants included men with prostate cancer and age- and race-frequency-matched population controls. Participants were recruited at the Baltimore Veterans Affairs Medical Center and University of Maryland Medical Center; controls were obtained through the Maryland Motor Vehicle Administration database. National Death Index follow-up was performed through December 31, 2020, and data analysis was conducted from February 1, 2022, through October 31, 2022. 2000 Census-tract Neighborhood Deprivation Index as a standardized score. Primary outcomes included prostate cancer, all-cause mortality, and disease-specific mortality. Secondary outcomes included the National Comprehensive Cancer Network risk score and serum proteomes for 82 immune-oncology markers with pathway annotation. Participants included men with prostate cancer (n = 769: 405 African American, 364 European American men) and age- and race-frequency-matched population controls (n = 1023: 479 African American, 544 European American men). The median survival follow-up was 9.70 years (IQR, 5.77 years), with 219 deaths. Among 884 African American men, mean (SD) age at recruitment was 63.8 (7.6) years; mean (SD) age at recruitment among 908 European American men was 66.4 (8.1) years. In the multivariable logistic regression analysis with individual socioeconomic status adjustment, neighborhood deprivation was associated with 55% increased odds of prostate cancer among African American men (odds ratio [OR], 1.55; 95% CI, 1.33-1.81), but was not associated with the disease among European American men. Residing in the most-deprived vs least-deprived neighborhoods corresponded to 88% higher disease odds (OR, 1.88; 95% CI, 1.30-2.75) among all men and an approximate 3-fold increase among African American men (OR, 3.58; 95% CI, 1.72-7.45), but no association was noted among European American men. In Cox proportional hazard regression analyses, socioeconomic status–adjusted neighborhood deprivation was associated with an increased all-cause mortality only among African American men (hazard ratio [HR], 1.28; 95% CI, 1.08-1.53), whereas it was associated with metastatic disease and a 50% increased hazard of a prostate cancer–specific death among all men (HR, 1.50; 95% CI, 1.07-2.09). In analyses restricted to controls, neighborhood deprivation was associated with increased activity scores of serum proteome-defined chemotaxis, inflammation, and tumor immunity suppression. The findings of this study suggest that deprived neighborhood residency may increase the risk of African American men for prostate cancer and a related mortality, potentially through its association with systemic immune function and inflammation.
登录
查看更多内容
影响因子：
2.8
作者：
Madhav, K. C.;Oral, Evrim;Rung, Ariane L.;Trapido, Edward J.;Rozek, Laura S.;Fontham, Elizabeth T. H.;Bensen, Jeannette T.;Farnan, Laura;Steck, Susan E.;Song, Lixin;Mohler, James L.;Peters, Edward S.
通讯作者：
Peters, Edward S.
DOI：
10.1007/s10552-018-1071-7
发表时间：
2018-10
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
DeRouen MC;Schupp CW;Yang J;Koo J;Hertz A;Shariff-Marco S;Cockburn M;Nelson DO;Ingles SA;Cheng I;John EM;Gomez SL
通讯作者：
Gomez SL
影响因子：
4.4
作者：
Dhabhar, Firdaus S.
通讯作者：
Dhabhar, Firdaus S.
影响因子：
4.8
作者：
Li, X.;Sundquist, K.;Sundquist, J.
通讯作者：
Sundquist, J.
非转移性普通癌症患者的邻居和个人社会经济劣势和生存率。
影响因子：
13.8
作者：
Cheng E;Soulos PR;Irwin ML;Cespedes Feliciano EM;Presley CJ;Fuchs CS;Meyerhardt JA;Gross CP
通讯作者：
Gross CP