Cortico-thalamic activation in generalized status epilepticus, a PET study
Cortico-thalamic activation in generalized status epilepticus, a PET study
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DOI：
10.1016/j.clineuro.2007.09.008
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发表时间：
2008-02-01
影响因子：
1.9
通讯作者：
van der Naalt, J.
中科院分区：
文献类型：
--
作者：
de Jong, B. M.;van de Hoeven, J. H.;van der Naalt, J.
在一个难治性全身性惊厥性癫痫持续状态的患者中，用正电子发射断层扫描（PET）评估了局部脑葡萄糖的发作分布。EEG中的同步癫痫发作活动与内侧感觉运动区、前扣带回、皮质、纹状体和丘脑的双侧代谢活化相关。这种局灶性皮质激活的模式支持皮质病灶可能驱动癫痫的概念，而丘脑介导EEG中反映的神经元活动的同步。(C)2007 Elsevier B.V.保留所有权利。
In a patient with a refractory generalized convulsive status epilepticus, the ictal distribution of regional cerebral glucose was assessed with positron emission tomography (PET). Synchronized seizure activity in the EEG was associated with bilateral metabolic activation of medial sensorimotor regions, anterior cingulate, cortex, striatum and thalamus. This pattern with focal cortical activation supports the concept that a cortical focus may drive epilepsy, while the thalamus mediates synchronization of neuronal activity as reflected in the EEG. (C) 2007 Elsevier B.V. All rights reserved.