Morphological Features of Complex Congenital Cardiovascular Anomalies in Fetuses: as Evaluated by Cast Models
Morphological Features of Complex Congenital Cardiovascular Anomalies in Fetuses: as Evaluated by Cast Models
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胎儿复杂先天性心血管异常的形态特征：通过铸型模型进行评估
DOI：
10.1007/s11596-017-1778-9
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发表时间：
2017-08-01
影响因子：
--
通讯作者：
Xie, Ming-xing
中科院分区：
文献类型：
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作者：
Cao, Hai-yan;Wang, Yu;Xie, Ming-xing
对复杂的先天性心血管畸形，特别是血管畸形的准确产前诊断仍然具有挑战性。胎儿心血管铸型模型可以提供具有正常或病理结构的心腔和大血管的副本。本研究旨在通过腐蚀铸造的方法对复杂的胎儿先天性心血管畸形进行三维解剖。本研究纳入了20例经产前超声诊断为复杂心血管畸形的胎儿(孕周19至35周)。采用腐蚀铸型技术制作胎儿心血管铸型模型。标本经脐静脉注入铸造物，铸造液固化后浸泡在强酸中，揭示心血管腔的几何形态。用20个标本成功制作了19个铸型模型。管型清晰地显示了心腔与大血管的形态畸形及空间关系。19例标本铸型发现异常111例，其中位于心腔内的异常34例(房室、房室瓣和脑室的异常分别为3、4和27例)，大血管的异常77例(主动脉及其分支、肺动脉、动脉导管和大静脉的异常分别为28、20、24和5例)。腐蚀铸型可显示胎儿复杂心血管畸形的三维解剖结构。这提高了我们对相关病理形态和产前诊断的理解。
Accurate prenatal diagnosis of complex congenital cardiovascular anomalies, vascular ones in particular, is still challenging. A fetal cardiovascular cast model can provide a copy of the cardiac chambers and great vessels with normal or pathological structures. This study was aimed to demonstrate three-dimensional anatomy of complex congenital cardiovascular anomalies in fetuses by means of corrosion casting. Twenty fetuses with prenatal-ultrasound-diagnosed complex cardiovascular anomalies were enrolled in this study (19 to 35 gestational weeks). Fetal cardiovascular cast models were made by a corrosion casting technique. The specimens were injected with casting material via the umbilical vein, and then immersed in strong acid after casting fluid was solidified, to disclose the geometries of cardiovascular cavities. Nineteen cast models were successfully made from 20 specimens. The casts distinctly showed the morphological malformations and spatial relationship between cardiac chambers and great vessels. One hundred and eleven abnormalities were revealed by casting in the 19 specimens, including 34 abnormalities located in the cardiac chambers (3, 4 and 27 anomalies in the atria, atrioventricular valves and ventricles, respectively), and 77 in the great vessels (28, 20, 24 and 5 anomalies in the aorta and its branches, the pulmonary artery, the ductus arteriosus and the major veins, respectively). Corrosion casting can display three-dimensional anatomy of fetal complex cardiovascular anomalies. This improves our understanding of related pathomorphology and prenatal diagnosis.