Current views on the role of Notch signaling and the pathogenesis of human leukemia.
Current views on the role of Notch signaling and the pathogenesis of human leukemia.
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当前关于Notch信号传导作用和人白血病发病机理的看法。
DOI：
10.1186/1471-2407-11-502
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发表时间：
2011-11-30
期刊：
影响因子：
3.8
通讯作者：
Nicot C
中科院分区：
文献类型：
--
作者：
Pancewicz J;Nicot C
Notch信号通路是从果蝇到人类高度保守的，并且在细胞增殖、分化和凋亡的调节中起重要作用。Notch信号传导的组成性激活已显示导致过度的细胞增殖和广泛的恶性肿瘤，包括白血病、胶质母细胞瘤以及肺癌和乳腺癌。Notch也可以作为肿瘤抑制因子，其失活与自发性鳞状细胞癌的风险增加有关。本文就Notch1、Notch2、Notch3和Notch4信号通路在人类淋巴细胞白血病、髓系白血病和B细胞淋巴瘤中的作用机制、意义以及Notch3靶向治疗的最新进展作一综述。
The Notch signaling pathway is highly conserved from Drosophila to humans and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of Notch signaling has been shown to result in excessive cellular proliferation and a wide range of malignancies, including leukemia, glioblastoma and lung and breast cancers. Notch can also act as a tumor suppressor, and its inactivation has been associated with an increased risk of spontaneous squamous cell carcinoma. This minireview focuses on recent advances related to the mechanisms and roles of activated Notch1, Notch2, Notch3 and Notch4 signaling in human lymphocytic leukemia, myeloid leukemia and B cell lymphoma, as well as their significance, and recent advances in Notch-targeted therapies.
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影响因子：
11.5
作者：
Mansour, Marc R.;Duke, Veronique;Linchl, David C.
通讯作者：
Linchl, David C.
影响因子：
11.4
作者：
Clappier, E.;Collette, S.;Cave, H.
通讯作者：
Cave, H.
影响因子：
8
作者：
Checquolo, S.;Palermo, R.;Screpanti, I.
通讯作者：
Screpanti, I.
影响因子：
4
作者：
Fortini, Mark E.;Bilder, David
通讯作者：
Bilder, David
影响因子：
2.6
作者：
Fu, Lu;Kogoshi, Hanae;Tohda, Shuji
通讯作者：
Tohda, Shuji