Glial cell regulation of rhythmic behavior.
Glial cell regulation of rhythmic behavior.
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DOI：
10.1016/bs.mie.2014.10.016
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发表时间：
2015
影响因子：
--
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Jackson FR;Ng FS;Sengupta S;You S;Huang Y
脑神经胶质细胞，特别是星形胶质细胞和小胶质细胞，分泌调节神经胶质-神经胶质或神经胶质-神经元通讯和突触活性的信号分子。虽然我们对神经胶质细胞在神经系统发育中的作用已经有了很多了解，但我们才刚刚开始了解这些细胞在成人大脑中的生理功能。在脊椎动物和无脊椎动物模型中的研究，特别是小鼠和果蝇，揭示了神经胶质-神经元通信在复杂行为调节中的作用。本章强调最近的证据，从啮齿动物和果蝇的研究，突出神经胶质细胞的重要性和相似性或差异的神经回路调节昼夜节律和睡眠的两个模型。本章讨论了细胞，分子和遗传的方法，这些方法在这些模型中是有用的，用于理解胶质神经元通信如何有助于调节节律行为。
Brain glial cells, in particular astrocytes and microglia, secrete signaling molecules that regulate glia–glia or glia–neuron communication and synaptic activity. While much is known about roles of glial cells in nervous system development, we are only beginning to understand the physiological functions of such cells in the adult brain. Studies in vertebrate and invertebrate models, in particular mice and Drosophila, have revealed roles of glia–neuron communication in the modulation of complex behavior. This chapter emphasizes recent evidence from studies of rodents and Drosophila that highlight the importance of glial cells and similarities or differences in the neural circuits regulating circadian rhythms and sleep in the two models. The chapter discusses cellular, molecular, and genetic approaches that have been useful in these models for understanding how glia–neuron communication contributes to the regulation of rhythmic behavior.