MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones.
MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones.
复制标题
MK801 在大鼠大脑皮质神经元中诱导即早期基因蛋白和 BDNF mRNA。
作者：
P. Hughes;M. Dragunow;E. Beilharz;P. Lawlor;P. Gluckman
Recent studies have shown that MK801, a potent phencyclidine receptor ligand, causes pathomorphological changes in rat cerebrocortical neurones. Here we report that doses of MK801 (1 and 5 mg kg-1) which have been shown to produce pathomorphological changes, induce the expression of immediate-early gene proteins (IEGPs) and brain-derived neurotrophic factor (BDNF) mRNA in rat cerebrocortical neurones. Blockade of central muscarinic receptors which has been shown to prevent MK801-induced pathomorphological changes in cerebrocortical neurones, also prevented MK801-induced expression of IEGPs and BDNF mRNA. The transiently increased expression of BDNF mRNA may be an acute compensatory response of these neurones to MK801-induced injury.
