Emotional memory in schizophrenia
Emotional memory in schizophrenia
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DOI：
10.1016/j.neuropsychologia.2006.10.012
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发表时间：
2007-01-01
期刊：
影响因子：
2.6
通讯作者：
Lawrie, Stephen M.
中科院分区：
文献类型：
--
作者：
Hall, Jeremy;Harris, Jonathan M.;Lawrie, Stephen M.
引起注意的场景比中性的场景更容易被记住。这种情绪记忆效应的生物学基础已经在损伤和神经成像研究中进行了研究，并取决于杏仁核和内侧颞叶记忆系统（包括海马体）之间的相互作用。本研究旨在探讨精神分裂症患者是否存在与杏仁核功能异常一致的情绪记忆任务表现缺陷。精神分裂症患者和匹配的对照组被展示了消极、积极和中性情绪内容的场景。受试者根据他们发现的情绪唤起程度对幻灯片进行评级，然后在10分钟（回忆）和3周（回忆和识别）时进行惊喜记忆测试。精神分裂症受试者与对照组受试者对幻灯片的评分没有差异。然而，患者表现出显着的损失的情绪增强识别记忆的消极和积极的场景。此外，患者在回忆记忆方面表现出整体缺陷，在回忆最令人兴奋的阴性幻灯片时表现出选择性障碍。这些发现与内侧颞叶，特别是杏仁核功能在精神分裂症中异常的观点一致。(c)2006爱思唯尔有限公司保留所有权利。
Emotionally arousing scenes are better remembered than neutral ones. The biological basis of this emotional memory effect has been studied in lesion and neuro-imaging studies and depends upon an interaction between the amygdala and medial temporal lobe memory systems including the hippocampus. This study sought to investigate whether patients with schizophrenia had performance deficits on emotional memory tasks consistent with abnormal amygdala function. Patients with schizophrenia and matched control subjects were shown scenes with negative, positive and neutral emotional content. Subjects rated the slides according to how emotionally arousing they found them and then performed surprise memory tests at 10 min (recall) and 3 weeks (recall and recognition). Subjects with schizophrenia did not differ from control subjects in their ratings of the slides. However, patients showed a significant loss of the emotional enhancement of recognition memory for both negative and positive scenes. In addition, patients showed an overall deficit in recall memory, with a selective impairment in recall of the most arousing negative slides. These findings are consistent with the view that medial temporal lobe and in particular amygdala function is abnormal in schizophrenia. (c) 2006 Elsevier Ltd. All rights reserved.