Haemoptysis in adults: a 5-year study using the French nationwide hospital administrative database
Haemoptysis in adults: a 5-year study using the French nationwide hospital administrative database
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DOI：
10.1183/09031936.00218214
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发表时间：
2015-08-01
影响因子：
24.3
通讯作者：
Quantin, Catherine
中科院分区：
文献类型：
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作者：
Abdulmalak, Caroline;Cottenet, Jonathan;Quantin, Catherine
咯血是一种严重的症状，病因多种多样。我们的目的是确定病因，结果和与肺癌在高收入国家的整个人群中的关联。这项回顾性多中心研究基于法国全国医院医疗信息数据库收集了5年（2008-2012）。我们分析了咯血的发病率、病因、地理和季节分布以及死亡率。我们研究了复发，与肺癌和死亡率在3年的随访分析。每年，类似的15000例成人患者（平均年龄62岁，男性/女性比例2/1）入院咯血或咯血作为其住院期间的并发症，占所有住院患者的0.2%。50%的咯血是隐源性的。主要病因为呼吸道感染（22%）、肺癌（17.4%）、支气管扩张（6.8%）、肺水肿（4.2%）、抗凝剂（3.5%）、结核（2.7%）、肺栓塞（2.6%）和曲霉菌病（1.1%）。在新发病例中，3年复发率为16.3%。在最初的隐源性咯血患者中，4%在3年内被诊断为肺癌。第一次住院期间、1年和3年的死亡率分别为9.2%、21.6%和27%.This is the first epidemiological study analyzing haemophysis and its outcomes in a whole population.咯血是一种危及生命的症状，揭示了潜在的危及生命的基础条件。
Haemoptysis is a serious symptom with various aetiologies. Our aim was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income country.This retrospective multicentre study was based on the French nationwide hospital medical information database collected over 5 years (2008-2012). We analysed haemoptysis incidence, aetiologies, geographical and seasonal distribution and mortality. We studied recurrence, association with lung cancer and mortality in a 3-year follow-up analysis.Each year, similar to 15000 adult patients (mean age 62 years, male/female ratio 2/1) were admitted for haemoptysis or had haemoptysis as a complication of their hospital stay, representing 0.2% of all hospitalised patients. Haemoptysis was cryptogenic in 50% of cases. The main aetiologies were respiratory infections (22%), lung cancer (17.4%), bronchiectasis (6.8%), pulmonary oedema (4.2%), anticoagulants (3.5%), tuberculosis (2.7%), pulmonary embolism (2.6%) and aspergillosis (1.1%). Among incident cases, the 3-year recurrence rate was 16.3%. Of the initial cryptogenic haemoptysis patients, 4% were diagnosed with lung cancer within 3 years. Mortality rates during the first stay and at 1 and 3 years were 9.2%, 21.6% and 27%, respectively.This is the first epidemiological study analysing haemoptysis and its outcomes in an entire population. Haemoptysis is a life-threatening symptom unveiling potentially life-threatening underlying conditions.