Personalized Reminders for Immunization Using Short Messaging Systems to Improve Human Papillomavirus Vaccination Series Completion: Parallel-Group Randomized Trial.
Personalized Reminders for Immunization Using Short Messaging Systems to Improve Human Papillomavirus Vaccination Series Completion: Parallel-Group Randomized Trial.
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DOI：
10.2196/26356
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发表时间：
2021-12-27
影响因子：
5
通讯作者：
Stockwell MS
中科院分区：
文献类型：
--
作者：
Wynn CS;Catallozzi M;Kolff CA;Holleran S;Meyer D;Ramakrishnan R;Stockwell MS
启动人乳头瘤病毒（HPV）疫苗3剂系列的青少年完成率很低。手机短信疫苗提醒是有效的，但对HPV系列完成的最佳类型或评估能力和目标疫苗决策阶段知之甚少。本研究的目的是比较HPV疫苗系列完成在少数青少年谁收到精确和教育与传统的短信提醒的有效性。在纽约市的4个学术附属社区卫生诊所之一接受第一剂HPV疫苗的9-17岁青少年的入组父母以1：1的比例随机分配到2个平行的非盲组之一：精确短信（包括针对阶段的教育信息，下一剂到期日和特定地点的步行时间）或没有教育信息的传统短信。根据性别、年龄和语言对随机化进行分层。主要结局是12个月内完成系列研究。在事后分析中，将入组者与同期非入组者和历史对照进行比较。共有956名家长参加了这项研究。精确（475个家庭）和传统（481个家庭）SMS短信组具有相似的高系列完成率（344/475，72.4% vs 364/481，75.7%）。在第一剂疫苗接种后的42天内，三分之二的家庭最初没有进入准备阶段，但进入了准备或接种阶段。短信组的完成率显著高于非参与者（708/1503，47.1% vs 679/1503，45.17%; P<0.001）。即使剔除那些只需要2次HPV注射的青少年，收到任何短信的青少年的完成率也高于历史对照组（337/2823，11.93% vs 981/2823，34.75%; P<.001）。从2014年到2016年，人们看到了全人口的影响，高于历史趋势。短信提醒使低收入、城市、少数民族研究人群及时完成HPV疫苗系列接种，并产生了全人群效应。教育信息并没有为这一群体提供额外的好处。ClinicalTrials.gov NCT02236273; https://clinicaltrials.gov/ct2/show/NCT02236273
Completion rates among adolescents who initiate the human papillomavirus (HPV) vaccine 3-dose series are low. SMS text message vaccine reminders are effective, but less is known about the best types for HPV series completion or the ability to assess and target vaccine decision-making stage. The aim of this study is to compare the effectiveness of HPV vaccine series completion in minority adolescents who received precision and educational versus conventional SMS text message reminders. Enrolled parents of adolescents aged 9-17 years who received the first HPV vaccine dose at 1 of the 4 academic-affiliated community health clinics in New York City were randomized 1:1 to 1 of the 2 parallel, unblinded arms: precision SMS text messages (which included stage-targeted educational information, next dose due date, and site-specific walk-in hours) or conventional SMS text messages without educational information. Randomization was stratified according to gender, age, and language. The primary outcome was series completion within 12 months. In post hoc analysis, enrollees were compared with concurrent nonenrollees and historical controls. Overall, 956 parents were enrolled in the study. The precision (475 families) and conventional (481 families) SMS text message arms had similarly high series completion rates (344/475, 72.4% vs 364/481, 75.7%). A total of 42 days after the first dose, two-thirds of families, not initially in the preparation stage, moved to preparation or vaccinated stage. Those in either SMS text message arm had significantly higher completion rates than nonenrollees (708/1503, 47.1% vs 679/1503, 45.17%; P<.001). Even after removing those needing only 2 HPV doses, adolescents receiving any SMS text messages had higher completion rates than historical controls (337/2823, 11.93% vs 981/2823, 34.75%; P<.001). A population-wide effect was seen from 2014 to 2016, above historical trends. SMS text message reminders led to timely HPV vaccine series completion in a low-income, urban, minority study population and also led to population-wide effects. Educational information did not provide an added benefit to this population. ClinicalTrials.gov NCT02236273; https://clinicaltrials.gov/ct2/show/NCT02236273