N6-Methyladenosine-Regulated mRNAs: Potential Prognostic Biomarkers for Patients With Lung Adenocarcinoma.
N6-Methyladenosine-Regulated mRNAs: Potential Prognostic Biomarkers for Patients With Lung Adenocarcinoma.
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N6-甲基腺苷调节的 mRNA：肺腺癌患者的潜在预后生物标志物
DOI：
10.3389/fcell.2021.705962
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发表时间：
2021
影响因子：
5.5
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Sun J;Ping Y;Huang J;Zeng B;Ji P;Li D
m6 A mRNA修饰的异常调节可导致基因表达的变化，从而促进几种类型的实体瘤的肿瘤发生。在这项研究中，通过整合m6 A甲基化和mRNA表达的分析，我们确定了84 m6 A调控的mRNA在肺腺癌（LUAD）。尽管LUAD患者肿瘤组织中总RNA的m6 A甲基化水平降低，但大多数（75.2%）m6 A调节的mRNA是高甲基化的。m6 A-高甲基化的mRNA主要富集在与转录因子活性相关的方面。通过最小绝对收缩和选择算子考克斯回归分析建立了10-m6 A调节的mRNA标签评分系统，并通过Kaplan-Meier曲线和时间依赖的受试者工作特征曲线验证了其预测价值。RFXAP和KHDRBS 2的签名也表现出独立的预后价值。共表达和相互作用网络分析证明了m6 A调节子与签名中的基因之间的强相关性，进一步支持了m6 A甲基化修饰模式的结果。这些发现强调了整合多组学数据（m6 A甲基化水平和mRNA表达）以准确获得潜在预后生物标志物的潜在效用，这可能为开发LUAD的新型有效疗法提供重要见解。
Aberrant regulation of m6A mRNA modification can lead to changes in gene expression, thus contributing to tumorigenesis in several types of solid tumors. In this study, by integrating analyses of m6A methylation and mRNA expression, we identified 84 m6A-regulated mRNAs in lung adenocarcinoma (LUAD). Although the m6A methylation levels of total RNA in LUAD patient tumor tissue were reduced, the majority (75.2%) of m6A-regulated mRNAs were hypermethylated. The m6A-hypermethylated mRNAs were mainly enriched in terms related to transcription factor activity. We established a 10-m6A-regulated-mRNA signature score system through least absolute shrinkage and selection operator Cox regression analysis, with its predictive value validated by Kaplan–Meier curve and time-dependent receiver operating characteristic curves. RFXAP and KHDRBS2 from the signature also exhibited an independent prognostic value. The co-expression and interaction network analyses demonstrated the strong correlation between m6A regulators and the genes in the signature, further supporting the results of the m6A methylation modification patterns. These findings highlight the potential utility of integrating multi-omics data (m6A methylation level and mRNA expression) to accurately obtain potential prognostic biomarkers, which may provide important insights into developing novel and effective therapies for LUAD.
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影响因子：
64.8
作者：
通讯作者：
--
长非编码RNA在神经回路组装和可塑性中的机制
影响因子：
3.5
作者：
Wang A;Wang J;Liu Y;Zhou Y
通讯作者：
Zhou Y
影响因子：
--
作者：
Ding G;Zhou L;Qian Y;Fu M;Chen J;Chen J;Xiang J;Wu Z;Jiang G;Cao L
通讯作者：
Cao L
胰腺癌中 m6A 调节因子的基因特征和预后价值的多组学综合分析：癌症基因组图谱项目的回顾性研究
DOI：
10.18632/aging.103942
发表时间：
2020-10-20
期刊：
Aging
影响因子：
--
作者：
Gao W;Cheng L;He S;Li W;Zhou C;Zhou B;Liu J;Xu J;Yu X;Zhu H
通讯作者：
Zhu H
影响因子：
4.7
作者：
Bai, Yang;Yang, Chunxing;Zhang, Yi
通讯作者：
Zhang, Yi