Studies on microperoxisomes. VII. Pigment epithelial cells and other cell types in the retina of rodents
Studies on microperoxisomes. VII. Pigment epithelial cells and other cell types in the retina of rodents
复制标题
微过氧化物酶体的研究。
DOI：
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复制
发表时间：
1975
影响因子：
7.8
通讯作者：
A. B. Novikoff
中科院分区：
文献类型：
--
作者：
P. Leuenberger;A. B. Novikoff
视网膜色素上皮细胞积极参与脂质代谢的两个方面：（a）维生素A的脂肪酸酯化及其储存和运输到光感受器，和（B）从光感受器细胞脱落的脂蛋白膜盘的吞噬和降解。对成年白化病和有色啮齿类动物的色素上皮细胞的研究揭示了一种细胞器--微过氧化物酶体的丰度，以前不知道这种细胞类型中存在这种细胞。脂质的代谢、运输和储存是其他细胞类型的主要功能，这些细胞类型具有大量与高度发达的滑面内质网相关的微过氧化物酶体。微过氧化物酶体，但相对较少，在米勒细胞和血管内皮细胞。感光末梢中的管状系统在用于可视化微过氧化物酶体的细胞化学过程中是反应性的。
The pigment epithelial cell of the retina actively participates in two aspects of lipid metabolism: (a) the fatty acid esterification of vitamin A and its storage and transport to the photoreceptors, and (b) the phagocytosis and degradation of the lipoprotein membrane disks shed from the photoreceptor cells. Study of the pigment epithelial cells of adult albino and pigmented rodents has revealed the abundance of an organelle, microperoxisomes, not previously known to exist in this cell type. The metabolism, transport, and storage of lipids are major functions of other cell types which possess large numbers of microperoxisomes associated with a highly developed smooth endoplasmic reticulum. Microperoxisomes were encountered, but relatively rarely, in Muller cells and vascular endothelial cells. A tubular system in photoreceptor terminals is reactive in the cytochemical procedure used to visualize microperoxisomes.