A Parameterized Ultrasound-Based Finite Element Analysis of the Mechanical Environment of Pregnancy.
A Parameterized Ultrasound-Based Finite Element Analysis of the Mechanical Environment of Pregnancy.
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基于参数化超声的妊娠机械环境有限元分析。
DOI：
10.1115/1.4036259
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Myers,KristinM
中科院分区：
文献类型：
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作者：
Westervelt,AndreaR;Fernandez,Michael;House,Michael;Vink,Joy;Nhan-Chang,Chia-Ling;Wapner,Ronald;Myers,KristinM
早产是儿童死亡的主要原因，并可能导致幸存者的健康风险。妊娠期间，子宫、胎膜和宫颈的机械功能对保护胎儿具有动态作用。为了解其力学功能及其与早产的关系，建立了妊娠期三维参数化有限元模型。该模型是由一个自动化的程序，是由产妇超声测量通知生成。对妊娠25周时的基线模型进行了表征，为了可视化颈椎结构参数对组织拉伸的影响，我们评估了模型对（1）子宫颈前角，（2）颈椎长度，（3）颈椎后偏移和（4）颈椎刚度的敏感性。我们发现，当宫颈管与子宫纵轴对齐时，宫颈组织的拉伸是最小的，并且较软的宫颈对所测试的几何变量的变化更敏感。
Preterm birth is the leading cause of childhood mortality and can lead to health risks in survivors. The mechanical functions of the uterus, fetal membranes, and cervix have dynamic roles to protect the fetus during gestation. To understand their mechanical function and relation to preterm birth, we built a three-dimensional parameterized finite element model of pregnancy. This model is generated by an automated procedure that is informed by maternal ultrasound measurements. A baseline model at 25 weeks of gestation was characterized, and to visualize the impact of cervical structural parameters on tissue stretch, we evaluated the model sensitivity to (1) anterior uterocervical angle, (2) cervical length, (3) posterior cervical offset, and (4) cervical stiffness. We found that cervical tissue stretching is minimal when the cervical canal is aligned with the longitudinal uterine axis, and a softer cervix is more sensitive to changes in the geometric variables tested.