The bone-implant interface - nanoscale analysis of clinically retrieved dental implants
The bone-implant interface - nanoscale analysis of clinically retrieved dental implants
复制标题
DOI：
10.1016/j.nano.2014.05.015
复制
发表时间：
2014-11-01
影响因子：
5.4
通讯作者：
Palmquist, Anders
中科院分区：
文献类型：
--
作者：
Shah, Furqan Ali;Nilson, Bengt;Palmquist, Anders
评估人体骨-植入物界面的精细结构是加深理解纳米改性生物材料结构与功能关系的先决条件。在这项研究中，使用组织学和界面超微结构分析评估了三种临床稳定但可恢复的激光修饰牙种植体。包含完整组织的所有线的累积结果显示，重塑的哈弗氏骨的骨面积和骨种植体接触分别超过 85% 和 80%。平行于表面氧化层放置的胶原原纤维被化学计量相关（Ca/P 比率 1.30-1.67）骨磷灰石的片状微晶矿化。钛、氧、钙和磷信号的重叠表明骨磷灰石和纳米粗糙表面氧化物逐渐混合。这些结果表明，在功能负载后，人体颌骨中纳米纹理钛种植体表面的骨结合得到促进。来自临床编辑：在这项研究中，新开发的激光改性钛牙种植体基于三种临床稳定牙种植体的表面和化学分析，证明了种植体与骨整合的有力证据。 (C) 2014 Elsevier Inc. 保留所有权利。
Evaluation of the fine structure of the bone-implant interface in humans is a prerequisite for a deepened understanding of structure-function relationships with nano-modified biomaterials. In this study, three clinically stable, yet retrieved, laser-modified dental implants were evaluated using histological and interface ultrastructural analyses. The cumulative results for all threads containing intact tissue showed remodeled Haversian bone with bone area and bone-implant contact in excess of 85% and 80%, respectively. Collagen fibrils, laid down parallel to the surface oxide layer, were mineralized by plate-like crystallites of stoichiometrically relevant (Ca/P ratios 1.30-1.67) bone-apatite. An overlap of titanium, oxygen, calcium and phosphorus signals indicated the gradual intermixing of bone-apatite and the nano-rough surface oxide. These results suggest that bone bonding to nano-textured titanium implant surfaces is promoted in human jaw-bone after functional loading.From the Clinical Editor: In this study, newly developed and laser-modified titanium dental implants demonstrate strong evidence for implant-osseo integration basen on the surface and chemical analysis of three clinically stable dental implants. (C) 2014 Elsevier Inc. All rights reserved.