No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
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DOI：
10.1038/jhg.2009.46
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发表时间：
2009-08-01
影响因子：
3.5
通讯作者：
Sasaki, Tsukasa
中科院分区：
文献类型：
--
作者：
Otowa, Takeshi;Shimada, Takafumi;Sasaki, Tsukasa
惊恐障碍(PD)是一种严重的慢性精神障碍，在病因中有重要的遗传成分。脑源性神经营养因子(BDNF)基因对5-羟色胺、多巴胺等神经递质系统具有调节作用，是帕金森病易感基因的候选基因。本研究调查了日本帕金森病患者和对照组中BDNF的三个单核苷酸多态(rs6265(Val66Met)、rs11030104和rs7103411)。未观察到这三个SNPs与帕金森病的显著关联。Val66Met与在日本和中国人群中进行的两项小规模研究没有关联。因此，我们得出结论，BDNF基因多态性在东亚人群帕金森病发病中可能不起主要作用。《人类遗传学杂志》(2009年)54,437-439；doi：10.1038/jhg.2009.46；在线发布
Panic disorder (PD) is a severe and chronic psychiatric disorder, with significant genetic components in the etiology. Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. This study investigated three single-nucleotide polymorphisms (SNPs) of BDNF (rs6265 (Val66Met), rs11030104 and rs7103411) in Japanese patients with PD and controls. No significant association was observed between the three SNPs and PD. No association of the Val66Met was consistent with two small studies in Japanese and Chinese populations. We therefore conclude that the BDNF polymorphism may not play a major role in PD in the East Asian populations. Journal of Human Genetics (2009) 54, 437-439; doi: 10.1038/jhg.2009.46; published online 22 May 2009