Crohn's disease is frequently complicated by giardiasis.
Crohn's disease is frequently complicated by giardiasis.
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克罗恩病经常并发贾第鞭毛虫病。
DOI：
10.3109/00365528809090769
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发表时间：
1988
影响因子：
1.9
通讯作者：
J. Lamina
中科院分区：
文献类型：
--
作者：
C. Scheurlen;W. Kruis;Ulrich Spengler;M. Weinzierl;Gustav Paumgartner;J. Lamina
贾第鞭毛虫病是一种常见的感染，其许多症状与克罗恩病相似。尽管人们对微生物制剂在克罗恩病中的作用进行了长期讨论，但贾第鞭毛虫病从未得到研究。我们研究了贾第鞭毛虫病，通过 86 名克罗恩病患者、82 名患有其他胃肠道疾病的患者和 52 名无胃肠道疾病的患者中包囊的发生情况进行评估。此外，在 20 名克罗恩病患者中研究了甲硝唑对贾第鞭毛虫病和疾病活动性的影响。克罗恩病患者中贾第鞭毛虫病的发生率为 61.6%，其他胃肠道疾病患者中贾第鞭毛虫病的发生率为 31.7%，对照组为 5.8%（p 小于 0.01）。克罗恩病患者的大便频率、疾病活动性和体液炎症体征与贾第鞭毛虫病无关。除两名接受甲硝唑治疗的患者外，所有患者均不再出现囊肿。 20 名患者中有 14 名克罗恩病活动指数下降（p 小于 0.05）。总之，贾第鞭毛虫病是克罗恩病患者的常见症状。在克罗恩病的个别病例中，贾第鞭毛虫病的治疗可以使疾病高活动性症状快速康复。
Giardiasis is a common infection, and many of its symptoms are similar to those of Crohn's disease. Despite a long discussion on the role of microbiologic agents in Crohn's disease, giardiasis has never been investigated. We studied giardiasis as assessed by the occurrence of cysts in 86 patients with Crohn's disease, in 82 patients with other gastrointestinal disease, and in 52 patients without gastrointestinal disease. In addition, in 20 patients with Crohn's disease the effects of metronidazole on giardiasis and disease activity were studied. Frequency of giardiasis was 61.6% in patients with Crohn's disease, 31.7% in patients with other gastrointestinal disease, and 5.8% in the control group (p less than 0.01). Stool frequency, disease activity, and humoral signs of inflammation in patients with Crohn's disease showed no relationship to giardiasis. All but two patients treated with metronidazole became free of cysts. Crohn's disease activity index decreased in 14 of 20 patients (p less than 0.05). In conclusion, giardiasis is a common finding in patients with Crohn's disease. Treatment of giardiasis can, in individual cases of Crohn's disease, result in a quick recovery from symptoms of high disease activity.