The hippocampus is necessary for enhancements and impairments of learning following stress
The hippocampus is necessary for enhancements and impairments of learning following stress
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DOI：
10.1038/nn1973
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发表时间：
2007-11-01
影响因子：
25
通讯作者：
Shors, Tracey J.
中科院分区：
文献类型：
--
作者：
Bangasser, Debra A.;Shors, Tracey J.
海马体通常被认为是压力和学习相互作用的重要场所;然而，从未证明这些影响是否需要海马体。在目前的研究中，海马损伤既防止了雄性大鼠应激后学习能力的增强，也防止了雌性大鼠应激后学习能力的受损，而不会破坏任何一种性别的学习能力。因此，海马是必要的修改学习后，男性和女性急性应激的经验。
The hippocampus is often considered to be an important site for stress and learning interactions; however, it has never been demonstrated whether these effects require the hippocampus. In the current study, hippocampal lesions prevented both enhancements of learning after stress in male rats and impairments of learning after stress in female rats without disrupting learning itself in either sex. Thus, the hippocampus is necessary for modifying learning in males and females after acute stressful experience.