Mitotic Mysteries: The Case of HP1.

Mitotic Mysteries: The Case of HP1.
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DOI:
10.1016/j.devcel.2016.02.019
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发表时间:
2016-03
期刊:
影响因子:
11.8
通讯作者:
J. Higgins;L. Prendergast
J. Higgins;L. Prendergast
中科院分区:
生物学1区
文献类型:
--
作者:
J. Higgins;L. Prendergast

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异染色质蛋白-1(HP1)在有丝分裂中的作用一直存在争议。Tanno等人最近在《科学》和《发育细胞》上的两项研究。(2015)和安倍等人。(2016),表明在染色体不稳定的癌细胞中,HP1定位的手段及其在内部着丝粒的功能发生了改变。
The role of Heterochromatin Protein-1 (HP1) during mitosis has been controversial. Two recent studies inScienceandDevelopmental Cell, from Tanno et al. (2015) and Abe et al. (2016), suggest that the means of HP1 localization and its function at inner centromeres are altered in cancer cells with chromosomal instability.